Collaboration with Other Institutions

Collaboration with the Niigata Bone Sciences Institute

This is a brief outline of bone histomorphometry and the activities of the Niigata Bone Sciences Institute.

Bone histomorphometry is a quantitative morphology of bone in tissue level, with a history of approximately 50 years since late 1950s. Using tetracycline antibiotics as a time-marker and undemineralized thin bone sections, it can assess histological dynamics of bone turnover, one of the important bone evaluation index.

The bone histomorphometry makes it possible to understand bone metabolic dynamics, which show bone turnover occurring constantly and continuously in both resorption and formation. The tissue level bone metabolism can be understood with its unique concepts, such as Basic Multicellular Unit (BMU), activation frequency, high turnover vs. low turnover osteoporosis, bone formation and resorption period, which does not know in cellular and molecular level physiology.

In recent years research into osteoporosis has become increasingly concerned with not only bone quantity but also bone quality. With bone histomorphometry we can identify the components of the quality of bone. Not only clinical materials, such as biopsied iliac bone specimen, but also the bones of monkeys, dogs, rats and mice can be objects of histomorphometric assessment.

Niigata bone science institute has a deep collaboration with orthopaedic department of Niigata university and Niigata university health and welfare. Also we have accepted many kinds of bone tissue from other universities and research institutes in Japan and abroad.

The osteoporosis is one of major diseases of aging society. Niigata bone science institute will have an important role in clinical and basic bone research.