リハビリテーション学部 Department of Physical Therapy

理学療法学科

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教員紹介

小島 翔写真

リハビリテーション学部／理学療法学科
Faculty of Rehabilitation／Department of Physical Therapy

小島 翔
Sho Kojima
講師

プロフィール

担当科目中枢神経系理学療法学、臨床実習Ⅲ
専門分野理学療法学、神経生理学
キーワード体性感覚機能，運動機能，脳活動，触覚刺激
学位・称号／取得機関／取得年博士（保健学）／新潟医療福祉大学／2016年
資格2010年度 理学療法士
過去の経歴東京湾岸リハビリテーション病院を経て現職
所属団体・学会等日本理学療法士協会、日本基礎理学療法学会、日本臨床神経生理学会、日本生体磁気学会、全国大学理学療法学教育学会、新潟医療福祉学会

外部リンク

業績等

研究領域触覚刺激の刺激方法の違いが大脳皮質の活動に及ぼす影響を明らかにする研究

一定時間の触覚刺激介入が運動機能および感覚機能に及ぼす影響を明らかにする研究

脳卒中患者に対する脳刺激効果の個人特性を明らかにする研究
研究紹介

日常生活の中で、我々は様々な刺激を感じながら生活しています。その中でも触覚（触った感覚）はとても重要な感覚の一つです。脳卒中などの疾患患者は触覚機能が低下していることが多く、この触覚機能の低下が運動機能の低下に結びついていると考えられています。しかしながら、その治療法は未だ確立されていません。そこで、我々は様々な触覚刺激（ツルツルやザラザラなど）介入が運動機能および感覚機能に及ぼす影響を明らかにする研究を行っています。これが明らかになれば、運動障害や感覚障害を持った患者様に対するリハビリテーションに応用できる可能性があると考えています。

受賞歴1. 2012年度 第11回新潟医療福祉学会学術集会　会頭賞受賞
2. 2016年度 The 10th ICME International Conference on Complex Medical Engineering．Best paper award受賞
3. 2017年度 2016年度笹川科学研究奨励賞
研究論文（和文）1. Kojima S, Miyaguchi S, Yokota H, Saito K, Inukai Y, Otsuru N, Onishi H. The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability. Brain Sci. 2021 Nov 12; 11(11):1494. doi: 10.3390/brainsci11111494.
2. Kojima S, Otsuru N, Miyaguchi S, Yokota H, Nagasaka K, Saito K, Inukai Y, Shirozu H, Onishi H. The intervention of mechanical tactile stimulation modulates somatosensory evoked magnetic fields and cortical oscillations. Eur J Neurosci. 2021 May; 53(10):3433-3446. doi: 10.1111/ejn.15209. Epub 2021 Apr 10.
3. Kojima S, Miyaguchi S, Sasaki R, Tsuiki S, Saito K, Inukai Y, Otsuru N, Onishi H. The effects of mechanical tactile stimulation on corticospinal excitability and motor function depend on pin protrusion patterns. Sci Rep. 2019 Nov 13; 9(1):16677. doi: 10.1038/s41598-019-53275-2.
4. Kojima S, Onishi H, Miyaguchi S, Kotan S, Sasaki R, Nakagawa M, Kirimoto H, Tamaki H. Modulation of corticospinal excitability depends on the pattern of mechanical tactile stimulation. Neural Plasticity. 2018 Apr 3; 2018:5383514. doi: 10.1155/2018/5383514. eCollection 2018.
5. Kojima S, Onishi H, Miyaguchi S, Kotan S, Sugawara K, Kirimoto H, Tamaki H. Effects of cathodal transcranial direct current stimulation to primary somatosensory cortex on short-latency afferent inhibition. Neuroreport. 2015 Aug 5; 26(11):634-7. doi: 10.1097/WNR.0000000000000402.
6. Kojima S, Onishi H, Sugawara K, Miyaguchi S, Kirimoto H, Tamaki H, Shirozu H, Kameyama S. No relation between afferent facilitation induced by digital nerve stimulation and the latency of cutaneomuscular reflexes and somatosensory evoked magnetic fields. Frontiers in Human Neuroscience. 2014 doi: 10.3389/fnhum.2014.01023.
7. Kojima S, Onishi H, Sugawara K, Kirimoto H, Suzuki M, Tamaki H. Modulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation. BMC Neurosci. 2013; 14:43. doi: 10.1186/1471-2202-14-43.
8. 小島　翔，宮口翔太，小丹晋一，桐本　光，田巻弘之，大西秀明． 末梢電気刺激による求心性抑制が二連発磁気刺激による皮質内興奮性に及ぼす影響． 理学療法学．
9. Pham MV, Saito K, Miyaguchi S, Watanabe H, Ikarashi H, Nagasaka K, Yokota H, Kojima S, Inukai Y, Otsuru N, Onishi H. Changes in excitability and GABAergic neuronal activity of the primary somatosensory cortex after motor learning. Front Neurosci. 2022 Sep 20; 16:794173. doi: 10.3389/fnins.2022.794173.
10. Kamii Y, Kojima S, Onishi H. Transcranial direct current stimulation over the posterior parietal cortex improves visuomotor performance and proprioception in the lower extremities. Front Hum Neurosci. 2022 Aug 18 16:876083. doi: 10.3389/fnhum.2022.876083.
11. Yokota H, Edama M, Hirabayashi R, Sekine C, Otsuru N, Saito K, Kojima S, Miyaguchi S, Onishi H. Effects of Stimulus Frequency, Intensity, and Sex on the Autonomic Response to Transcutaneous Vagus Nerve Stimulation. Brain Sci. 2022 Aug 4; 12(8):1038. doi: 10.3390/brainsci12081038.
12. Onishi H, Nagasaka K, Yokota H, Kojima S, Ohno K, Sakurai N, Kodama N, Sato D, Otsuru N. Association between somatosensory sensitivity and regional gray matter volume in healthy young volunteers: a voxel-based morphometry study. Cereb Cortex. 2023 Feb 20; 33(5):2001-2010. doi: 10.1093/cercor/bhac188.
13. Saito K, Otsuru N, Inukai Y, Kojima S, Miyaguchi S, Nagasaka K, Onishi H. Effect of Transcranial Electrical Stimulation over the Posterior Parietal Cortex on Tactile Spatial Discrimination Performance. Neuroscience. 2022 Jul 1; 494:94-103.
14. Sakai S, Saito K, Kojima S, Otsuru N, Onishi H. Grating orientation task trial numbers for short- and long-term tactile discrimination learning. J Clin Neurosci. 2021 Nov; 93:195-199. doi: 10.1016/j.jocn.2021.08.026. Epub 2021 Sep 22.
15. Sasaki R, Kojima S, Onishi H. Do Brain-Derived Neurotrophic Factor Genetic Polymorphisms Modulate the Efficacy of Motor Cortex Plasticity Induced by Non-invasive Brain Stimulation? A Systematic Review. Front Hum Neurosci. 2021 Sep 28; 15:742373. doi: 10.3389/fnhum.2021.742373. eCollection 2021.
16. Watanabe H, Kojima S, Nagasaka K, Ohno K, Sakurai N, Kodama N, Otsuru N, Onishi H. Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype. Cereb Cortex. 2021 Oct 11: bhab370. doi: 10.1093/cercor/bhab370. Online ahead of print.
17. Otsuru N, Ogawa M, Yokota H, Miyaguchi S, Kojima S, Saito K, Inukai Y, Onishi H. Auditory change-related cortical response is associated with hypervigilance to pain in healthy volunteers. Eur J Pain. 2022 Feb; 26(2):349-355. doi: 10.1002/ejp.1863. Epub 2021 Sep 22.
18. Hoshi H, Kojima S, Otsuru N, Onishi H. Effects of transcranial random noise stimulation timing on corticospinal excitability and motor function. Behav Brain Res. 2021 Sep 24; 414:113479. doi: 10.1016/j.bbr.2021.113479. Epub 2021 Jul 21.
19. Yokota H, Otsuru N, Saito K, Kojima S, Miyaguchi S, Inukai Y, Nagasaka K, Onishi H. Region-Specific Effects of 10-Hz Transcranial Alternate Current Stimulation Over the Left Posterior Parietal Cortex and Primary Somatosensory Area on Tactile Two-Point Discrimination Threshold. Front Neurosci. 2021 Feb 18; 15:576526. doi: 10.3389/fnins.2021.576526. eCollection 2021.
20. Hoshi H, Kojima S, Otsuru N, Onishi H. Corticospinal excitability of untrained side depends on the type of motor task and degree of improvement in motor function. Brain Cogn. 2021 Mar; 148:105691. doi: 10.1016/j.bandc.2021.105691. Epub 2021 Jan 27.
21. Saito K, Otsuru N, Yokota H, Inukai Y, Miyaguchi S, Kojima S, Onishi H. α-tACS over the somatosensory cortex enhances tactile spatial discrimination in healthy subjects with low alpha activity. Brain Behav. 2021 Jan 6: e02019. doi: 10.1002/brb3.2019. Online ahead of print.
22. Hirabayashi R, Kojima S, Edama M, Onishi H. Activation of the Supplementary Motor Areas Enhances Spinal Reciprocal Inhibition in Healthy Individuals. Brain Sci. 2020 Aug 24; 10(9):587. doi: 10.3390/brainsci10090587.
23. Hirabayashi R, Edama M, Kojima S, Miyaguchi S, Onishi H. Enhancement of spinal reciprocal inhibition depends on the movement speed and range of repetitive passive movement. Eur J Neurosci. 2020 Oct; 52(8):3929-3943.
24. Watanabe H, Kojima S, Otsuru N, Onishi H. The Repetitive Mechanical Tactile Stimulus Intervention Effects Depend on Input Methods. Front Neurosci. 2020 Apr 28; 14:393. doi: 10.3389/fnins.2020.00393. eCollection 2020.
25. Inukai Y, Otsuru N, Saito K, Miyaguchi S, Kojima S, Yokota H, Nagasaka K, Onishi H. The after-effect of noisy galvanic vestibular stimulation on postural control in young people: A randomized controlled trial. Neurosci Lett. 2020 Jun 11; 729:135009. doi: 10.1016/j.neulet.2020.135009. Epub 2020 Apr 25.
26. Otsuru N, Miyaguchi S, Kojima S, Yamashiro K, Sato D, Yokota H, Saito K, Inukai Y, Onishi H. Timing of Modulation of Corticospinal Excitability by Heartbeat Differs with Interoceptive Accuracy. Neuroscience. 2020 May 1; 433:156-162. doi: 10.1016/j.neuroscience.2020.03.014. Epub 2020 Mar 17.
27. Hirabayashi R, Edama M, Kojima S, Miyaguchi S, Onishi H. Effects of repetitive passive movement on ankle joint on spinal reciprocal inhibition. Exp Brain Res. 2019 Dec; 237(12):3409-3417. doi: 10.1007/s00221-019-05689-7. Epub 2019 Nov 14.
28. Yokota H, Otsuru N, Kikuchi R, Suzuki R, Kojima S, Saito K, Miyaguchi S, Inukai Y, Onishi H. Establishment of optimal two-point discrimination test method and consideration of reproducibility. Neurosci Lett. 2020 Jan 1; 714:134525. doi: 10.1016/j.neulet.2019.134525. Epub 2019 Sep 30.
29. Yamazaki Y, Yamashiro K, Onishi H, Otsuru N, Kojima S, Saito K, Sato D. Modulation of inhibitory function in the primary somatosensory cortex and temporal discrimination threshold induced by acute aerobic exercise. Behav Brain Res. 2020 Jan 13; 377:112253. doi: 10.1016/j.bbr.2019.112253. Epub 2019 Sep 21.
30. Saito K, Otsuru N, Inukai Y, Miyaguchi S, Yokota H, Kojima S, Sasaki R, Onishi H. Comparison of transcranial electrical stimulation regimens for effects on inhibitory circuit activity in primary somatosensory cortex and tactile spatial discrimination performance. Behav Brain Res. 2019 Dec 16; 375:112168. doi: 10.1016/j.bbr.2019.112168. Epub 2019 Aug 20.
31. Miyaguchi S, Yamaguchi M, Kojima S, Yokota H, Saito K, Inukai Y, Otsuru N, Onishi H. Time course of bilateral corticospinal tract excitability in the motor-learning process. Neurosci Lett. 2019 Oct 15; 711:134410. doi: 10.1016/j.neulet.2019.134410. Epub 2019 Aug 16.
32. Otsuru N, Kamijo K, Otsuki T, Kojima S, Miyaguchi S, Saito K, Inukai Y, Onishi H. 10Hz transcranial alternating current stimulation over posterior parietal cortex facilitates tactile temporal order judgment. Behav Brain Res. 2019 Aug 5; 368:111899. doi: 10.1016/j.bbr.2019.111899. Epub 2019 Apr 9.
33. Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, Onishi H. The effect of gamma tACS over the M1 region and cerebellar hemisphere does not depend on current intensity. J Clin Neurosci. 2019 Jul; 65:54-58. doi: 10.1016/j.jocn.2019.03.045. Epub 2019 Apr 3.
34. Tsuiki S, Sasaki R, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H. The effect of combined transcranial direct current stimulation and peripheral nerve electrical stimulation on corticospinal excitability. PLoS One. 2019 Mar 29; 14(3):e0214592. doi: 10.1371/journal.pone.0214592. eCollection 2019.
35. Hirabayashi R, Edama M, Kojima S, Ito W, Nakamura E, Kikumoto T, Onishi H. Spinal reciprocal inhibition in the co-contraction of the lower leg depends on muscle activity ratio. Exp Brain Res. 2019 Jun; 237(6):1469-1478. doi: 10.1007/s00221-019-05523-0. Epub 2019 Mar 21.
36. Tsuiki S, Sasaki R, Pham MV, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Repetitive Passive Movement Modulates Corticospinal Excitability: Effect of Movement and Rest Cycles and Subject Attention. Front Behav Neurosci. 2019 Mar 1; 13:38. doi: 10.3389/fnbeh.2019.00038. eCollection 2019.
37. Hirabayashi R, Edama M, Kojima S, Nakamura M, Ito W, Nakamura E, Kikumoto T, Onishi H. Effects of Reciprocal Ia Inhibition on Contraction Intensity of Co-contraction. Front Hum Neurosci. 2019 Jan 11; 12:527. doi: 10.3389/fnhum.2018.00527. eCollection 2018.
38. Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, Onishi H. Gamma tACS over M1 and cerebellar hemisphere improves motor performance in a phase-specific manner. Neurosci Lett. 2019 Feb 16; 694:64-68. doi: 10.1016/j.neulet.2018.11.015. Epub 2018 Nov 13.
39. Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Repetitive Passive Finger Movement Modulates Primary Somatosensory Cortex Excitability. Front Hum Neurosci. 2018 Aug 20; 12:332. doi: 10.3389/fnhum.2018.00332. eCollection 2018.
40. Miyaguchi S, Otsuru N, Kojima S, Saito K, Inukai Y, Masaki M, Onishi H. Transcranial Alternating Current Stimulation With Gamma Oscillations Over the Primary Motor Cortex and Cerebellar Hemisphere Improved Visuomotor Performance. Front Behav Neurosci. 2018 Jul 5; 12:132. doi: 10.3389/fnbeh.2018.00132. eCollection 2018.
41. Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Somatosensory Inputs Induced by Passive Movement Facilitate Primary Motor Cortex Excitability Depending on the Interstimulus Interval, Movement Velocity, and Joint Angle. Neuroscience. 2018 Aug 21; 386:194-204. doi: 10.1016/j.neuroscience.2018.06.042. Epub 2018 Jul 4.
42. Inukai Y, Masaki M, Otsuru N, Saito K, Miyaguchi S, Kojima S, Onishi H. Effect of noisy galvanic vestibular stimulation in community-dwelling elderly people: a randomised controlled trial. J Neuroeng Rehabil. 2018 Jul 3; 15(1):63. doi: 10.1186/s12984-018-0407-6.
43. Saito K, Otsuru N, Inukai Y, Kojima S, Miyaguchi S, Tsuiki S, Sasaki R, Onishi H. Inhibitory Mechanisms in Primary Somatosensory Cortex Mediate the Effects of Peripheral Electrical Stimulation on Tactile Spatial Discrimination. Neuroscience. 2018 Aug 1; 384:262-274. doi: 10.1016/j.neuroscience.2018.05.032. Epub 2018 Jun 1.
44. Onishi H, Otsuru N, Kojima S, Miyaguchi S, Saito K, Inukai Y, Yamashiro K, Sato D, Tamaki H, Shirozu H, Kameyama S. Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation. Brain Topogr. 2018 Sep; 31(5):780-794. doi: 10.1007/s10548-018-0648-5. Epub 2018 May 8.
45. Inukai Y, Otsuru N, Masaki M, Saito K, Miyaguchi S, Kojima S, Onishi H. Effect of noisy galvanic vestibular stimulation on center of pressure sway of static standing posture. Brain Stimul. 2018 Jan-Feb; 11(1):85-93. doi: 10.1016/j.brs.2017.10.007. Epub 2017 Oct 17.
46. Miyaguchi S, Kojima S, Sasaki R, Tamaki H, Onishi H. Modulation of short-latency afferent inhibition and short-interval intracortical inhibition by test stimulus intensity and motor-evoked potential amplitude. Neuroreport. 2017 Dec 13; 28(18):1202-1207. doi: 10.1097/WNR.0000000000000896.
47. Otsuka R, Sasaki R, Tsuiki S, Kojima S, Onishi H. Post-exercise cortical depression following repetitive passive finger movement. Neurosci Lett. 2017 Aug 24; 656:89-93. doi: 10.1016/j.neulet.2017.07.030. Epub 2017 Jul 19.
48. Miyaguchi S, Kojima S, Sasaki R, Kotan S, Kirimoto H, Tamaki H, Onishi H. Decrease in short-latency afferent inhibition during corticomotor postexercise depression following repetitive finger movement. Brain Behav. 2017 Jun 9; 7(7):e00744. doi: 10.1002/brb3.744. eCollection 2017 Jul.
49. Tsubaki A, Takehara N, Sato D, Morishita S, Tokunaga Y, Sugawara K, Kojima S, Tamaki H, Yamazaki Y, Onishi H. Cortical Oxyhemoglobin Elevation Persists After Moderate-Intensity Cycling Exercise: A Near-Infrared Spectroscopy Study. Adv Exp Med Biol. 2017; 977:261-268. doi: 10.1007/978-3-319-55231-6_36.
50. Sasaki R, Nakagawa M, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H. Regulation of primary motor cortex excitability by repetitive passive finger movement frequency. Neuroscience. 2017 Aug 15; 357:232-240. doi: 10.1016/j.neuroscience.2017.06.009. Epub 2017 Jun 14.
51. Nakagawa M, Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Onishi H. Effects of Passive Finger Movement on Cortical Excitability. Front Hum Neurosci. 2017 May 3; 11:216. doi: 10.3389/fnhum.2017.00216. eCollection 2017.
52. Sasaki R, Kotan S, Nakagawa M, Miyaguchi S, Kojima S, Saito K, Inukai Y, Onishi H. Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability. Front Hum Neurosci. 2017 Mar 24; 11:146. doi: 10.3389/fnhum.2017.00146. eCollection 2017.
53. Inukai Y, Saito K, Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Masaki M, Otsuru N, Onishi H. Comparison of Three Non-Invasive Transcranial Electrical Stimulation Methods for Increasing Cortical Excitability. Front Hum Neurosci. 2016 Dec 27; 10:668. doi: 10.3389/fnhum.2016.00668. eCollection 2016.
54. Sugawara K, Onishi H, Yamashiro K, Kotan S, Kojima S, Miyaguchi S, Tsubaki A, Kirimoto H, Tamaki H, Shirozu H, Kameyama S. Effect of muscle contraction strength on gating of somatosensory magnetic fields. Exp Brain Res. 2016 Nov; 234(11):3389-3398. doi: 10.1007/s00221-016-4736-z. Epub 2016 Jul 19.
55. Tsubaki A, Takai H, Oyanagi K, Kojima S, Tokunaga Y, Miyaguchi S, Sugawara K, Sato D, Tamaki H, Onishi H. Correlation Between the Cerebral Oxyhaemoglobin Signal and Physiological Signals During Cycling Exercise: A Near-Infrared Spectroscopy Study. Adv Exp Med Biol. 2016; 923:159-166. doi: 10.1007/978-3-319-38810-6_21.
56. Miyaguchi S, Kojima S, Kirimoto H, Tamaki H, Onishi H. Do Differences in Levels, Types, and Duration of Muscle Contraction Have an Effect on the Degree of Post-exercise Depression?. Front Hum Neurosci. 2016 Apr 29; 10:159. doi: 10.3389/fnhum.2016.00159. eCollection 2016.
57. Sugawara K, Onishi H, Yamashiro K, Kojima S, Miyaguchi S, Kotan S, Tsubaki A, Kirimoto H, Tamaki H, Shirozu H, Kameyama S. Effect of Range and Angular Velocity of Passive Movement on Somatosensory Evoked Magnetic Fields. Brain Topogr. 2016 Sep; 29(5):693-703. doi: 10.1007/s10548-016-0492-4. Epub 2016 Apr 13.
58. Sasaki R, Miyaguchi S, Kotan S, Kojima S, Kirimoto H, Onishi H. Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex. Front Hum Neurosci. 2016 Feb 4; 10:30. doi: 10.3389/fnhum.2016.00030. eCollection 2016.
59. Tsubaki A, Takai H, Kojima S, Miyaguchi S, Sugawara K, Sato D, Tamaki H, Onishi H. Changes in Cortical Oxyhaemoglobin Signal During Low-Intensity Cycle Ergometer Activity: A Near-Infrared Spectroscopy Study. Adv Exp Med Biol. 2016; 876:79-85. doi: 10.1007/978-1-4939-3023-4_10.
60. Kotan S, Kojima S, Miyaguchi S, Sugawara K, Onishi H. Depression of corticomotor excitability after muscle fatigue induced by electrical stimulation and voluntary contraction. Front Hum Neurosci. 2015 Jun 19; 9:363. doi: 10.3389/fnhum.2015.00363. eCollection 2015.
61. Kirimoto H, Tamaki H, Suzuki M, Matsumoto T, Sugawara K, Kojima S, Onishi H. Sensorimotor modulation differs with load type during constant finger force or position. PLoS One. 2014 Sep 18; 9(9):e108058. doi: 10.1371/journal.pone.0108058. eCollection 2014.
62. Sugawara K, Onishi H, Yamashiro K, Kojima S, Miyaguchi S, Kirimoto H, Tsubaki A, Tamaki H, Shirozu H, Kameyama S. The effect of anodal transcranial direct current stimulation over the primary motor or somatosensory cortices on somatosensory evoked magnetic fields. Clin Neurophysiol. 2015 Jan; 126(1):60-7. doi: 10.1016/j.clinph.2014.04.014. Epub 2014 May 4.
63. Miyaguchi S, Onishi H, Kojima S, Sugawara K, Tsubaki A, Kirimoto H, Tamaki H, Yamamoto N. Corticomotor excitability induced by anodal transcranial direct current stimulation with and without non-exhaustive movement. Brain Res. 2013 Sep 5; 1529:83-91. doi: 10.1016/j.brainres.2013.07.026. Epub 2013 Jul 24.
64. Tsubaki A, Kojima S, Furusawa AA, Onishi H. Effect of valsalva maneuver-induced hemodynamic changes on brain near-infrared spectroscopy measurements. Adv Exp Med Biol. 2013; 789:97-103. doi: 10.1007/978-1-4614-7411-1_14.
科学研究費1. 2021年度-2024年度 基盤研究（B） 「触圧覚刺激に対する皮質応答および個人差の解明と脳卒中リハビリテーションへの展開」
2. 2019年度-2020年度 若手研究 「触覚刺激による介入が皮質間ネットワークおよび知覚学習に及ぼす影響」
3. 2017年度-2018年度 若手研究 「機械的触覚刺激による介入が感覚機能および一次体性感覚野の興奮性に及ぼす影響」
4. 2016年度 その他 「機械的触覚刺激による介入が皮質脊髄路の興奮性に及ぼす影響」
共同研究・受託研究 等1. 2021年度 研究助成金 「個人の脳構造特性から非侵襲的脳刺激法による運動機能向上効果を予測する」
2. 2019年度 研究助成金 「感覚機能に特異的に関連するネットワークの解明」
3. 2017年度 研究助成金 「機械的触覚刺激による介入が感覚機能および一次体性感覚野の興奮性に及ぼす影響」
4. 2016年度 研究助成金 「受動的および能動的触覚刺激による介入が皮質脊髄路興奮性に及ぼす影響」
学内委員会活動1. 図書館・学習支援センター運営委員会（委員・企画開発推進部会部会長）

Profile

Research AreasNeuromadulation in human by NIBS and somatosensory stimulation, somatosenosry processing in human brain
Research IntroductionThe cortical activity following the mechanical tactile stimulation depends on the tactile stimulation patterns, and prolonged mechanical tactile stimulation or non-invasive brain stimulation modulates the cortical excitability. Therefore, we investigated whether the effects of mechanical tactile stimulus intervention or non-invasive brain stimulation on somatosensory function and cortical function.
Papers[First Author]

1. Kojima S, Miyaguchi S, Yokota H, Saito K, Inukai Y, Otsuru N, Onishi H. The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability. Brain Sci. 2021 Nov 12;11(11):1494. doi: 10.3390/brainsci11111494.

2. Kojima S, Otsuru N, Miyaguchi S, Yokota H, Nagasaka K, Saito K, Inukai Y, Shirozu H, Onishi H. The intervention of mechanical tactile stimulation modulates somatosensory evoked magnetic fields and cortical oscillations. Eur J Neurosci. 2021 May;53(10):3433-3446. doi: 10.1111/ejn.15209. Epub 2021 Apr 10.

3. Kojima S, Miyaguchi S, Sasaki R, Tsuiki S, Saito K, Inukai Y, Otsuru N, Onishi H. The effects of mechanical tactile stimulation on corticospinal excitability and motor function depend on pin protrusion patterns. Sci Rep. 2019 Nov 13;9(1):16677. doi: 10.1038/s41598-019-53275-2.

4. Kojima S, Onishi H, Miyaguchi S, Kotan S, Sasaki R, Nakagawa M, Kirimoto H, Tamaki H. Modulation of corticospinal excitability depends on the pattern of mechanical tactile stimulation. Neural Plasticity. 2018　Apr 3;2018:5383514. doi: 10.1155/2018/5383514. eCollection 2018.

5. Kojima S, Onishi H, Miyaguchi S, Kotan S, Sugawara K, Kirimoto H, Tamaki H. Effects of cathodal transcranial direct current stimulation to primary somatosensory cortex on short-latency afferent inhibition. Neuroreport. 2015 Aug 5;26(11):634-7. doi: 10.1097/WNR.0000000000000402.

6. Kojima S, Onishi H, Sugawara K, Miyaguchi S, Kirimoto H, Tamaki H, Shirozu H, Kameyama S. No relation between afferent facilitation induced by digital nerve stimulation and the latency of cutaneomuscular reflexes and somatosensory evoked magnetic fields. Frontiers in Human Neuroscience. 2014 doi: 10.3389/fnhum.2014.01023.

7. Kojima S, Onishi H, Sugawara K, Kirimoto H, Suzuki M, Tamaki H. Modulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation. BMC Neurosci. 2013; 14:43. doi: 10.1186/1471-2202-14-43.

[Co-author]

1. Sakai S, Saito K, Kojima S, Otsuru N, Onishi H. Grating orientation task trial numbers for short- and long-term tactile discrimination learning. J Clin Neurosci. 2021 Nov;93:195-199. doi: 10.1016/j.jocn.2021.08.026. Epub 2021 Sep 22.

2. Sasaki R, Kojima S, Onishi H. Do Brain-Derived Neurotrophic Factor Genetic Polymorphisms Modulate the Efficacy of Motor Cortex Plasticity Induced by Non-invasive Brain Stimulation? A Systematic Review. Front Hum Neurosci. 2021 Sep 28;15:742373. doi: 10.3389/fnhum.2021.742373. eCollection 2021.

3. Watanabe H, Kojima S, Nagasaka K, Ohno K, Sakurai N, Kodama N, Otsuru N, Onishi H. Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype. Cereb Cortex. 2021 Oct 11:bhab370. doi: 10.1093/cercor/bhab370. Online ahead of print.

4. Otsuru N, Ogawa M, Yokota H, Miyaguchi S, Kojima S, Saito K, Inukai Y, Onishi H. Auditory change-related cortical response is associated with hypervigilance to pain in healthy volunteers. Eur J Pain. 2022 Feb;26(2):349-355. doi: 10.1002/ejp.1863. Epub 2021 Sep 22.

5. Hoshi H, Kojima S, Otsuru N, Onishi H. Effects of transcranial random noise stimulation timing on corticospinal excitability and motor function. Behav Brain Res. 2021 Sep 24;414:113479. doi: 10.1016/j.bbr.2021.113479. Epub 2021 Jul 21.

6. Yokota H, Otsuru N, Saito K, Kojima S, Miyaguchi S, Inukai Y, Nagasaka K, Onishi H. Region-Specific Effects of 10-Hz Transcranial Alternate Current Stimulation Over the Left Posterior Parietal Cortex and Primary Somatosensory Area on Tactile Two-Point Discrimination Threshold. Front Neurosci. 2021 Feb 18;15:576526. doi: 10.3389/fnins.2021.576526. eCollection 2021.

7. Hoshi H, Kojima S, Otsuru N, Onishi H. Corticospinal excitability of untrained side depends on the type of motor task and degree of improvement in motor function. Brain Cogn. 2021 Mar;148:105691. doi: 10.1016/j.bandc.2021.105691. Epub 2021 Jan 27.

8. Saito K, Otsuru N, Yokota H, Inukai Y, Miyaguchi S, Kojima S, Onishi H. α-tACS over the somatosensory cortex enhances tactile spatial discrimination in healthy subjects with low alpha activity. Brain Behav. 2021 Jan 6:e02019. doi: 10.1002/brb3.2019. Online ahead of print.

9. Hirabayashi R, Kojima S, Edama M, Onishi H. Activation of the Supplementary Motor Areas Enhances Spinal Reciprocal Inhibition in Healthy Individuals. Brain Sci. 2020 Aug 24;10(9):587. doi: 10.3390/brainsci10090587.

10. Hirabayashi R, Edama M, Kojima S, Miyaguchi S, Onishi H. Enhancement of spinal reciprocal inhibition depends on the movement speed and range of repetitive passive movement. Eur J Neurosci. 2020 Oct;52(8):3929-3943.

11. Watanabe H, Kojima S, Otsuru N, Onishi H. The Repetitive Mechanical Tactile Stimulus Intervention Effects Depend on Input Methods. Front Neurosci. 2020 Apr 28;14:393. doi: 10.3389/fnins.2020.00393. eCollection 2020.

12. Inukai Y, Otsuru N, Saito K, Miyaguchi S, Kojima S, Yokota H, Nagasaka K, Onishi H. The after-effect of noisy galvanic vestibular stimulation on postural control in young people: A randomized controlled trial. Neurosci Lett. 2020 Jun 11;729:135009. doi: 10.1016/j.neulet.2020.135009. Epub 2020 Apr 25.

13. Otsuru N, Miyaguchi S, Kojima S, Yamashiro K, Sato D, Yokota H, Saito K, Inukai Y, Onishi H. Timing of Modulation of Corticospinal Excitability by Heartbeat Differs with Interoceptive Accuracy. Neuroscience. 2020 May 1;433:156-162. doi: 10.1016/j.neuroscience.2020.03.014. Epub 2020 Mar 17.

14. Hirabayashi R, Edama M, Kojima S, Miyaguchi S, Onishi H. Effects of repetitive passive movement on ankle joint on spinal reciprocal inhibition. Exp Brain Res. 2019 Dec;237(12):3409-3417. doi: 10.1007/s00221-019-05689-7. Epub 2019 Nov 14.

15. Yokota H, Otsuru N, Kikuchi R, Suzuki R, Kojima S, Saito K, Miyaguchi S, Inukai Y, Onishi H. Establishment of optimal two-point discrimination test method and consideration of reproducibility. Neurosci Lett. 2020 Jan 1;714:134525. doi: 10.1016/j.neulet.2019.134525. Epub 2019 Sep 30.

16. Yamazaki Y, Yamashiro K, Onishi H, Otsuru N, Kojima S, Saito K, Sato D. Modulation of inhibitory function in the primary somatosensory cortex and temporal discrimination threshold induced by acute aerobic exercise. Behav Brain Res. 2020 Jan 13;377:112253. doi: 10.1016/j.bbr.2019.112253. Epub 2019 Sep 21.

17. Saito K, Otsuru N, Inukai Y, Miyaguchi S, Yokota H, Kojima S, Sasaki R, Onishi H. Comparison of transcranial electrical stimulation regimens for effects on inhibitory circuit activity in primary somatosensory cortex and tactile spatial discrimination performance. Behav Brain Res. 2019 Dec 16;375:112168. doi: 10.1016/j.bbr.2019.112168. Epub 2019 Aug 20.

18. Miyaguchi S, Yamaguchi M, Kojima S, Yokota H, Saito K, Inukai Y, Otsuru N, Onishi H. Time course of bilateral corticospinal tract excitability in the motor-learning process. Neurosci Lett. 2019 Oct 15;711:134410. doi: 10.1016/j.neulet.2019.134410. Epub 2019 Aug 16.

19. Otsuru N, Kamijo K, Otsuki T, Kojima S, Miyaguchi S, Saito K, Inukai Y, Onishi H. 10Hz transcranial alternating current stimulation over posterior parietal cortex facilitates tactile temporal order judgment. Behav Brain Res. 2019 Aug 5;368:111899. doi: 10.1016/j.bbr.2019.111899. Epub 2019 Apr 9.

20. Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, Onishi H. The effect of gamma tACS over the M1 region and cerebellar hemisphere does not depend on current intensity. J Clin Neurosci. 2019 Jul;65:54-58. doi: 10.1016/j.jocn.2019.03.045. Epub 2019 Apr 3.

21. Tsuiki S, Sasaki R, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H. The effect of combined transcranial direct current stimulation and peripheral nerve electrical stimulation on corticospinal excitability. PLoS One. 2019 Mar 29;14(3):e0214592. doi: 10.1371/journal.pone.0214592. eCollection 2019.

22. Hirabayashi R, Edama M, Kojima S, Ito W, Nakamura E, Kikumoto T, Onishi H. Spinal reciprocal inhibition in the co-contraction of the lower leg depends on muscle activity ratio. Exp Brain Res. 2019 Jun;237(6):1469-1478. doi: 10.1007/s00221-019-05523-0. Epub 2019 Mar 21.

23. Tsuiki S, Sasaki R, Pham MV, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Repetitive Passive Movement Modulates Corticospinal Excitability: Effect of Movement and Rest Cycles and Subject Attention. Front Behav Neurosci. 2019 Mar 1;13:38. doi: 10.3389/fnbeh.2019.00038. eCollection 2019.

24. Hirabayashi R, Edama M, Kojima S, Nakamura M, Ito W, Nakamura E, Kikumoto T, Onishi H. Effects of Reciprocal Ia Inhibition on Contraction Intensity of Co-contraction. Front Hum Neurosci. 2019 Jan 11;12:527. doi: 10.3389/fnhum.2018.00527. eCollection 2018.

25. Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, Onishi H. Gamma tACS over M1 and cerebellar hemisphere improves motor performance in a phase-specific manner. Neurosci Lett. 2019 Feb 16;694:64-68. doi: 10.1016/j.neulet.2018.11.015. Epub 2018 Nov 13.

26. Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Repetitive Passive Finger Movement Modulates Primary Somatosensory Cortex Excitability. Front Hum Neurosci. 2018 Aug 20;12:332. doi: 10.3389/fnhum.2018.00332. eCollection 2018.

27. Miyaguchi S, Otsuru N, Kojima S, Saito K, Inukai Y, Masaki M, Onishi H. Transcranial Alternating Current Stimulation With Gamma Oscillations Over the Primary Motor Cortex and Cerebellar Hemisphere Improved Visuomotor Performance. Front Behav Neurosci. 2018 Jul 5;12:132. doi: 10.3389/fnbeh.2018.00132. eCollection 2018.

28. Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Somatosensory Inputs Induced by Passive Movement Facilitate Primary Motor Cortex Excitability Depending on the Interstimulus Interval, Movement Velocity, and Joint Angle. Neuroscience. 2018 Aug 21;386:194-204. doi: 10.1016/j.neuroscience.2018.06.042. Epub 2018 Jul 4.

29. Inukai Y, Masaki M, Otsuru N, Saito K, Miyaguchi S, Kojima S, Onishi H. Effect of noisy galvanic vestibular stimulation in community-dwelling elderly people: a randomised controlled trial. J Neuroeng Rehabil. 2018 Jul 3;15(1):63. doi: 10.1186/s12984-018-0407-6.

30. Saito K, Otsuru N, Inukai Y, Kojima S, Miyaguchi S, Tsuiki S, Sasaki R, Onishi H. Inhibitory Mechanisms in Primary Somatosensory Cortex Mediate the Effects of Peripheral Electrical Stimulation on Tactile Spatial Discrimination. Neuroscience. 2018 Aug 1;384:262-274. doi: 10.1016/j.neuroscience.2018.05.032. Epub 2018 Jun 1.

31. Onishi H, Otsuru N, Kojima S, Miyaguchi S, Saito K, Inukai Y, Yamashiro K, Sato D, Tamaki H, Shirozu H, Kameyama S. Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation. Brain Topogr. 2018 Sep;31(5):780-794. doi: 10.1007/s10548-018-0648-5. Epub 2018 May 8.

32. Inukai Y, Otsuru N, Masaki M, Saito K, Miyaguchi S, Kojima S, Onishi H. Effect of noisy galvanic vestibular stimulation on center of pressure sway of static standing posture. Brain Stimul. 2018 Jan-Feb;11(1):85-93. doi: 10.1016/j.brs.2017.10.007. Epub 2017 Oct 17.

33. Miyaguchi S, Kojima S, Sasaki R, Tamaki H, Onishi H. Modulation of short-latency afferent inhibition and short-interval intracortical inhibition by test stimulus intensity and motor-evoked potential amplitude. Neuroreport. 2017 Dec 13;28(18):1202-1207. doi: 10.1097/WNR.0000000000000896.

34. Otsuka R, Sasaki R, Tsuiki S, Kojima S, Onishi H. Post-exercise cortical depression following repetitive passive finger movement. Neurosci Lett. 2017 Aug 24;656:89-93. doi: 10.1016/j.neulet.2017.07.030. Epub 2017 Jul 19.

35. Miyaguchi S, Kojima S, Sasaki R, Kotan S, Kirimoto H, Tamaki H, Onishi H. Decrease in short-latency afferent inhibition during corticomotor postexercise depression following repetitive finger movement. Brain Behav. 2017 Jun 9;7(7):e00744. doi: 10.1002/brb3.744. eCollection 2017 Jul.

36. Tsubaki A, Takehara N, Sato D, Morishita S, Tokunaga Y, Sugawara K, Kojima S, Tamaki H, Yamazaki Y, Onishi H. Cortical Oxyhemoglobin Elevation Persists After Moderate-Intensity Cycling Exercise: A Near-Infrared Spectroscopy Study. Adv Exp Med Biol. 2017;977:261-268. doi: 10.1007/978-3-319-55231-6_36.

37. Sasaki R, Nakagawa M, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H. Regulation of primary motor cortex excitability by repetitive passive finger movement frequency. Neuroscience. 2017 Aug 15;357:232-240. doi: 10.1016/j.neuroscience.2017.06.009. Epub 2017 Jun 14.

38. Nakagawa M, Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Onishi H. Effects of Passive Finger Movement on Cortical Excitability. Front Hum Neurosci. 2017 May 3;11:216. doi: 10.3389/fnhum.2017.00216. eCollection 2017.

39. Sasaki R, Kotan S, Nakagawa M, Miyaguchi S, Kojima S, Saito K, Inukai Y, Onishi H. Presence and Absence of Muscle Contraction Elicited by Peripheral Nerve Electrical Stimulation Differentially Modulate Primary Motor Cortex Excitability. Front Hum Neurosci. 2017 Mar 24;11:146. doi: 10.3389/fnhum.2017.00146. eCollection 2017.

40. Inukai Y, Saito K, Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Masaki M, Otsuru N, Onishi H. Comparison of Three Non-Invasive Transcranial Electrical Stimulation Methods for Increasing Cortical Excitability. Front Hum Neurosci. 2016 Dec 27;10:668. doi: 10.3389/fnhum.2016.00668. eCollection 2016.

41. Sugawara K, Onishi H, Yamashiro K, Kotan S, Kojima S, Miyaguchi S, Tsubaki A, Kirimoto H, Tamaki H, Shirozu H, Kameyama S. Effect of muscle contraction strength on gating of somatosensory magnetic fields. Exp Brain Res. 2016 Nov;234(11):3389-3398. doi: 10.1007/s00221-016-4736-z. Epub 2016 Jul 19.

42. Tsubaki A, Takai H, Oyanagi K, Kojima S, Tokunaga Y, Miyaguchi S, Sugawara K, Sato D, Tamaki H, Onishi H. Correlation Between the Cerebral Oxyhaemoglobin Signal and Physiological Signals During Cycling Exercise: A Near-Infrared Spectroscopy Study. Adv Exp Med Biol. 2016;923:159-166. doi: 10.1007/978-3-319-38810-6_21.

43. Miyaguchi S, Kojima S, Kirimoto H, Tamaki H, Onishi H. Do Differences in Levels, Types, and Duration of Muscle Contraction Have an Effect on the Degree of Post-exercise Depression?. Front Hum Neurosci. 2016 Apr 29;10:159. doi: 10.3389/fnhum.2016.00159. eCollection 2016.

44. Sugawara K, Onishi H, Yamashiro K, Kojima S, Miyaguchi S, Kotan S, Tsubaki A, Kirimoto H, Tamaki H, Shirozu H, Kameyama S. Effect of Range and Angular Velocity of Passive Movement on Somatosensory Evoked Magnetic Fields. Brain Topogr. 2016 Sep;29(5):693-703. doi: 10.1007/s10548-016-0492-4. Epub 2016 Apr 13.

45. Sasaki R, Miyaguchi S, Kotan S, Kojima S, Kirimoto H, Onishi H. Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex. Front Hum Neurosci. 2016 Feb 4;10:30. doi: 10.3389/fnhum.2016.00030. eCollection 2016.

46. Tsubaki A, Takai H, Kojima S, Miyaguchi S, Sugawara K, Sato D, Tamaki H, Onishi H. Changes in Cortical Oxyhaemoglobin Signal During Low-Intensity Cycle Ergometer Activity: A Near-Infrared Spectroscopy Study. Adv Exp Med Biol. 2016;876:79-85. doi: 10.1007/978-1-4939-3023-4_10.

47. Kotan S, Kojima S, Miyaguchi S, Sugawara K, Onishi H. Depression of corticomotor excitability after muscle fatigue induced by electrical stimulation and voluntary contraction. Front Hum Neurosci. 2015 Jun 19;9:363. doi: 10.3389/fnhum.2015.00363. eCollection 2015.

48. Kirimoto H, Tamaki H, Suzuki M, Matsumoto T, Sugawara K, Kojima S, Onishi H. Sensorimotor modulation differs with load type during constant finger force or position. PLoS One. 2014 Sep 18;9(9):e108058. doi: 10.1371/journal.pone.0108058. eCollection 2014.

49. Sugawara K, Onishi H, Yamashiro K, Kojima S, Miyaguchi S, Kirimoto H, Tsubaki A, Tamaki H, Shirozu H, Kameyama S. The effect of anodal transcranial direct current stimulation over the primary motor or somatosensory cortices on somatosensory evoked magnetic fields. Clin Neurophysiol. 2015 Jan;126(1):60-7. doi: 10.1016/j.clinph.2014.04.014. Epub 2014 May 4.

50. Miyaguchi S, Onishi H, Kojima S, Sugawara K, Tsubaki A, Kirimoto H, Tamaki H, Yamamoto N. Corticomotor excitability induced by anodal transcranial direct current stimulation with and without non-exhaustive movement. Brain Res. 2013 Sep 5;1529:83-91. doi: 10.1016/j.brainres.2013.07.026. Epub 2013 Jul 24.

51. Tsubaki A, Kojima S, Furusawa AA, Onishi H. Effect of valsalva maneuver-induced hemodynamic changes on brain near-infrared spectroscopy measurements. Adv Exp Med Biol. 2013;789:97-103. doi: 10.1007/978-1-4614-7411-1_14.
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