理学療法学科教員紹介

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理学療法学科 メニュー

学科トップ 目標とする資格 学びの特色 カリキュラム 施設・設備 学外実習 ゼミ紹介 就職状況 在学生
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卒業生
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教員紹介

大鶴 直史写真

リハビリテーション学部/理学療法学科

大鶴 直史
Naofumi Otsuru
准教授

プロフィール

担当科目理学療法基礎評価学Ⅱ、物理療法学、神経筋機能解析学
専門分野神経科学、脳機能計測
学位・称号/取得機関/取得年博士(理学)/総合研究大学院大学/2010年
資格理学療法士
最終出身校総合研究大学院大学生命科学研究科生理科学専攻博士課程
過去の経歴自然科学研究機構生理学研究所博士研究員、広島大学大学院医歯薬保健学研究院助教を経て現職
所属団体・学会等日本理学療法士協会、日本臨床神経生理学会、日本生体磁気学会、北米神経科学学会、日本運動器疼痛学会、日本ペインリハビリテーション学会

業績等

研究領域神経科学、痛みの脳内情報処理、慢性疼痛臨床研究
研究紹介リハビリテーションを必要とされる患者さんの多くが、からだに痛みを抱えておられます。その中には、治療が難しい痛みも含まれています。痛みに関連する脳活動を調べることによって、痛みがどのように生み出されるか、またどのようにすれば痛みを抑えられるかに関する研究をしています。
著書リハビリテーション神経科学 (メジカルビュー社)
受賞歴【すべて筆頭】
4th Asian and Oceanian Congress of Clinical Neurophysiology, 2009: Travel Award
29th International Congress of Clinical Neurophysiology, 2010: Young Investigator Award
第26回日本生体磁気学会 2011年:奨励賞(35歳以下)
計測自動制御学会 2017年:技術奨励賞
研究論文1. Otsuru N, Miyaguchi S, Kojima S, Yamashiro K, Sato D, Yokota H, Saito K, Inukai Y, Onishi H. Timing of modulation of corticospinal excitability by heartbeat differs with interoceptive accuracy. Neuroscience 433, 156-162, 2020
2. Inukai Y, Otsuru N, Saito K, Kojima S, Nagasaka K, Yokota H, Miyaguchi S, Onishi H. The after effect of galvanic vestibular stimulation on postural control in young people: a randomized controlled trial. Neuroscience Letters, 2020, in press.
3. Watanabe H, Kojima S, Otsuru N, Onishi H. The repetitive mechanical tactile stimulus intervention effects depend on input methods. Frontiers in Neuroscience 14, 393, 2020
4. Yamazaki Y, Yamashiro K, Onishi H, Otsuru N, Kojima S, Saito K, Sato D. Modulation of inhibitory function in the primary somatosensory cortex and temporal discrimination threshold induced by acute aerobic exercise. Behavioural Brain Research 377, 112253, 2020.
5. Kojima S, Miyaguchi S, Sasaki R, Tsuiki S, Saito K, Inukai Y, Otsuru N, Onishi H. The effects of mechanical tactile stimulation on corticospinal excitability and motor function depend on pin protrusion patterns. Scientific Reports 9, 16677, 2019
6. Otsuru N, Kamijo K, Otsuki T, Kojima S, Miyaguchi S, Saito K, Inukai Y, Onishi H. 10 Hz transcranial alternating current stimulation over posterior parietal cortex facilitates tactile temporal order judgment, Behavioural Brain Research 368, 111899, 2019.
7. Saito K, Otsuru N, Inukai Y, Miyaguchi S, Yokota H, Kojima S, Sasaki R, Onishi H. Comparison of transcranial electrical stimulation regimens for effects on inhibitory circuit activity in primary somatosensory cortex and tactile spatial discrimination performance. Behavioural Brain Research 375, 112168, 2019
8. Yokota H, Otsuru N, Kikuchi R, Suzuki R, Kojima S, Saito K, Miyaguchi S, Inukai Y, Onishi H. Establishment of optimal two-point discrimination test method and consideration of reproducibility. Neuroscience Letters 714, 134525, 2020
9. Abe T, Miyaguchi S, Otsuru N, Onishi H. The effect of transcranial random noise stimulation on corticospinal excitability and motor performance. Neuroscience Letter 705: 138-142, 2019.
10. Tsuiki S, Sasaki R, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H. The effect of combined transcranial direct current stimulation and peripheral nerve electrical stimulation on corticospinal excitability. PLOS One 14, e0214592, 2019.
11. Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, Onishi H. The effect of gamma tACS over the M1 region and cerebellar hemisphere does not depend on current intensity. Journal of Clinical Neuroscience, 65, 54-58, 2019
12. Tsuiki S, Sasaki R, Pham Van Manh, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Repetitive passive movement modulates corticospinal excitability: Effect of movement and rest cycles and subject attention. Frontiers in Behavioral Neuroscience, 2019, in press
13. Miyaguchi S, Otsuru N, Kojima S, Yokota H, Saito K, Inukai Y, Onishi H. Gamma tACS over M1 and cerebellar hemisphere improves motor performance in a phase-specific manner. Neurosci Lett 694: 64-68, 2019
14. Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Somatosensory inputs induced by passive movement facilitate primary motor cortex excitability depending on the interstimulus interval, movement velocity, and joint angle. Neuroscience 386: 194-204, 2018
15. Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Otsuru N, Onishi H. Repetitive passive finger movement modulates primary somatosensory cortex excitability. Frontiers in Human Neuroscience 2018; 12: 332
16. Inukai Y, Masaki M, Otsuru N, Saito K, Miyaguchi S, Kojima S, Onishi H. The effect of noisy galvanic vestibular stimulation in community-dwelling elderly people: a randomized controlled trial. Journal of NeuroEngineering and Rehabilitation 2018; 3: 15
17. Miyaguchi S, Otsuru N, Kojima S, Saito K, Inukai Y, Masaki M, Onishi H. Transcranial alternating current stimulation with gamma oscillations over the primary motor cortex and cerebellar hemisphere improved visuomotor performance. Frontiers in Behavioral Neuroscience 2018; 12: 132.
18. Saito K, Otsuru N, Inukai Y, Kojima S, Miyaguchi S, Tsuiki S, Sasaki R, Onishi H. Inhibitory Mechanisms in Primary Somatosensory Cortex Mediate the Effects of Peripheral Electrical Stimulation on Tactile Spatial Discrimination. Neuroscience 2018; 384: 262-274.
19. Onishi H, Otsuru N, Kojima S, Miyaguchi S, Saito K, Inukai Y, Yamashiro K, Sato D, Tamaki H, Shirozu H, Kameyama S. Variability and Reliability of Paired-Pulse Depression and Cortical Oscillation Induced by Median Nerve Stimulation. Brain topography 2018; 31: 780-794.
20. Inukai Y, Otsuru N, Masaki M, Saito K, Miyaguchi S, Kojima S, Onishi H. Effect of noisy galvanic vestibular stimulation on center of pressure sway of static standing posture. Brain Stimulation 2017; 11: 85-93.
21. Yoshino A, Okamoto Y, Doi M, Otsuru N, Okada G, Takamura M, Ichikawa N, Yokoyama S, Yamashita H, Yamawaki S. Regional brain functions in the resting state indicative of potential differences between depression and chronic pain. Scientific Reports 2017; 7: 30003.
22. Kirimoto H, Tamaki H, Otsuru N, Yamashiro K, Onishi H, Nojima I, Oliviero A. Transcranial static magnetic field stimulation over the primary motor cortex induces plastic changes in cortical nociceptive processing. Frontiers Human Neuroscience 2018; 12: 63
23. Sasaki R, Nakagawa M, Tsuiki S, Miyaguchi S, Kojima S, Saito K, Inukai Y, Masaki M, Otsuru N, Onishi H: Regulation of primary motor cortex excitability by repetitive passive finger movement frequency. Neuroscience 357: 232-240, 2017
24. Imura T, Tomiyasu M, Otsuru N, Nakagawa K, Otsuka T, Takahasi S, Takeda M, Shrestha L, Kawahara Y, Fukazawa T, Sueda T, Tanimoto K, Yuge L: Hypoxic preconditioning increases the neuroprotective effects of mesenchymal stem cells in a rat model of spinal cord injury. J Stem Cell Res Ther 7: 375, 2017
25. Inukai Y, Saito K, Sasaki R, Tsuiki S, Miyaguchi S, Kojima S, Masaki M, Otsuru N, Onishi H: Comparison of three non-invasive transcranial electrical stimulation methods for increasing cortical excitability. Front Hum Neurosci 10: 668, 2016
26. Yoshino A, Okamoto Y, Doi M, Horikoshi M, Oshita K, Nakamura R, Otsuru N, Yoshimura S, Tanaka K, Takagaki K, Jinnin R, Yamashita H, Kawamoto M, Yamawaki S: Effectiveness of group cognitive behavioral therapy (GCBT) for somatoform pain disorder patients in Japan: A preliminary non-case-control study. Psychiat Clin Neurosci 69: 763-772, 2015
27. Nishihara M, Inui K, Morita T, Kodaira M, Mochizuki H, Otsuru N, Motomura E, Ushida T, Kakigi R: Echoic memory: Investigation of its temporal resolution analyzed by auditory offset cortical responses. PLOS ONE 9: e106553, 2014
28. Otsuru N, Hashizume A, Nakamura D, Endo Y, Inui K, Kakigi R, Yuge L: Sensory incongruence leading to hand disownership modulates somatosensory cortical processing. Cortex 58:1-8, 2014
29. Nakagawa K, Otsuru N, Inui K, Kakigi R: Change-related auditory P50: A MEG study. NeuroImage 86:131 -137, 2014
30. Omori S, Isose S, Otsuru N, Nishihara M, Kuwabara S, Inui K, Kakigi R: Somatotopic representation of pain in the primary somatosensory cortex (SI) in humans. Clin Neurophysiol 124:1422-1430, 2013
31. Otsuru N, Tsuruhara A, Motomura E, Tanii H, Nishihara M, Inui K, Kakigi R: Effects of acute nicotine on auditory change-related cortical responses. Psychopharmacology 224:327-335, 2012
32. Ohoyama K, Motomura E, Inui K, Nishihara M, Otsuru N, Oi M, Kakigi R, Okada M: Memory-based pre-attentive auditory N1 elicited by sound movement. Neurosci Res 73:248-251, 2012
33. Keceli S, Inui K, Okamoto H, Otsuru N, Kakigi R: Auditory sustained field responses to periodic noise. BMC Neurosci 13: 7, 2012
34. Yamashiro K, Inui K, Otsuru N, Urakawa T, Kakigi R: Temporal window of integration in the somatosensory modality: An MEG study. Clin Neurophysiol 122:2276-2281, 2011
35. Nishihara M, Inui K, Motomura E, Otsuru N, Ushida T, Kakigi R: Auditory N1 as a change-related automatic response. Neurosci Res 71:145-148, 2011
36. Otsuru N, Inui K, Yamashiro K, Urakawa T, Keceli S, Kakigi R: Effects of prior sustained tactile stimulation on the somatosensory response to the sudden change of intensity in humans: an magnetoencephalography study. Neuroscience 182:115 -124, 2011
37. Inui K, Urakawa T, Yamashiro K, Otsuru N, Takeshima Y, Nishihara M, Motomura E, Kida T, Kakigi R: Echoic memory of a single pure tone indexed by change-related brain activity. BMC Neurosci 11:135, 2010
38. Inui K, Urakawa T, Yamashiro K, Otsuru N, Nishihara M, Takeshima Y, Keceli S, Kakigi R: Non-linear laws of echoic memory and auditory change detection in humans. BMC Neurosci 11: 80, 2010
39. Yamashiro K, Inui K, Otsuru N, Kakigi R: Change-related response in the human auditory cortex: An MEG study. Psychophysiology 48:23-30, 2010
40. Otsuru N, Inui K, Yamashiro K, Miyazaki T, Takeshima Y, Kakigi R: Assessing A-delta fiber function with lidocaine using intra-epidermal electrical stimulation. J Pain 11:621-627, 2010
41. Mochizuki H, Inui K, Tanabe HC, Akiyama LF, Otsuru N, Yamashiro K, Sasaki A, Nakata H, Sadato N, Kakigi R: Time course of activity in itch-related brain regions: A combined MEG-fMRI study. J Neurophysiol 102:2657-2666, 2009
42. Otsuru N, Inui K, Yamashiro K, Miyazaki T, Ohsawa I, Takeshima Y, Kakigi R: Selective stimulation of C fibers by an Intra-epidermal needle electrode in humans. The Open Pain Journal 2:53-56, 2009
43. Yamashiro K, Inui K, Otsuru N, Kida T, Kakigi R: Automatic auditory off-response in humans: an MEG study. European Journal of Neuroscience 30:125-131, 2009
44. Yamashiro K, Inui K, Otsuru N, Kida T, Kakigi R: Somatosensory off response in humans: an MEG study. NeuroImage 44:1363-1368, 2009
45. Yamashiro K, Inui K, Otsuru N, Kida T, Akatsuka K, Kakigi R: Somatosensory off response in humans: an ERP study. Exp Brain Res 190:207-213, 2008
46. Mochizuki H, Inui K, Yamashiro K, Otsuru N, Kakigi R: Itching-related somatosensory evoked potentials. Pain 138:598-603, 2008
研究業績研究代表のみ記載
2011年 生理学研究所若手研究者育成支援 
2012年~2015年 科学研究費補助金 若手研究(B) 「知覚―運動ループの不一致が痛覚および変化検出機構に及ぼす影響」
2015年~2018年 科学研究費補助金 若手研究(B) 「自己身体認知の変化を誘発するリハビリテーション戦略の開発」 
2018年~    科学研究費補助金 挑戦的研究(萌芽) 「バーチャルリアリティとロボティクスを応用した心拍駆動型身体認知変容システムの開発」
2019年~    科学研究費補助金 基盤研究(B) 「慢性疼痛に対する認知行動療法の効果を向上させる脳内ネットワーク刺激戦略」
社会的活動愛知県理学療法学会学術誌部 部員 (2011年まで)
Frontiers in human neuroscience誌 review editor
新潟疼痛懇話会 役員 
日本理学療法士協会「理学療法学」編集委員
全国大学理学療法学教育学会 庶務 
日本生体磁気学会 評議員 
日本ペインリハビリテーション学会 代議員