7/14勉強会

【研究報告】

担当：Hewanayakage Chamoda Bimali Jayasinghe さん

Title：BIOMARKERS OF BRAIN PLASTICITY INDUCED BY TRANSCRANIAL STATIC MAGNETIC FIELD STIMULATION (tSMS)

  • Background：Transcranial static magnetic field stimulation (tSMS) is a safe and inexpensive non-invasive brain stimulation (NIBS) technique that modulates cortical excitability. The effects of NIBS vary depending on numerous factors, including genetic polymorphisms. Brain-derived neurotrophic factor (BDNF) is essential for neuronal growth, survival, and synaptic plasticity, while catechol-O-methyltransferase (COMT) plays a key role in regulating neurotransmitter levels. Both BDNF and COMT exhibit genetic polymorphisms, which may lead to variability in the effects of NIBS. However, their influence on the effects of tSMS remains unknown. This study investigates the impact of BDNF and COMT genetic polymorphisms on brain plasticity induced by tSMS.
  • Methods：This is a single-blinded, sham-controlled, crossover study.Sixty healthy adults from Niigata University of Health and Welfare are included in the sample. BDNF and COMT analyses are performed to identify the genetic polymorphisms. Each participant undergoes both real and sham interventions on two separate days, at least three days apart. Participants are blinded to the type of intervention. Motor-evoked potentials (MEPs) are assessed before (pre), immediately after (post 1), and 10 minutes after (post 2) the intervention, using transcranial magnetic stimulation (TMS) and electromyography (EMG). Corticospinal excitability and short-interval intracortical inhibition (SICI) are analyzed.
  • Data collection is ongoing.