健康科学部 Department of Health and Nutrition
健康栄養学科
教員紹介
健康科学部／健康栄養学科
Faculty of Health Sciences／Department of Health and Nutrition
馬場 広子
Baba Hiroko
教授（特任）
プロフィール
| 担当科目 | 臨床薬理学 |
|---|---|
| 専門分野 | 神経科学、神経内科学、機能形態学 |
| 学位・称号／取得機関／取得年 | 博士（医学）／新潟大学／1997年 |
| 資格 | （1980年5月） 医師免許 |
| 所属団体・学会等 | 日本神経学会 日本神経化学会 日本薬理学会 日本分子生物学会 日本薬学会 Society for Neuroscience American Society for Neurochemistry International Society for Neurochemisty |
外部リンク
業績等
| 研究領域 | 神経科学 |
|---|---|
| 研究紹介 | 神経系を構成する細胞は神経細胞とグリア細胞に大別されます。グリアは神経細胞同士がつくる神経回路の形成や機能に対して様々な調節を行なっています。また、グリアの異常は神経系の病気にも深く関わっています。特に神経細胞軸索の周囲にグリアが作り出す髄鞘という膜様構造物の働きや形成機序、髄鞘が壊れる（脱髄）疾患の病態やその再生機構に興味を持っています。 |
| 著書 | 1. グラフィカル機能形態学（第2版） 馬場広子編著 京都廣川書店, 2020 2. グラフィカル機能形態学 確認問題演習 馬場広子編著 京都廣川書店, 2018 |
| 研究論文（英文） | 1. Setoguchi Y, Hayashi A, Kawada A, Ibusuki A, Yanaoka D, Saito R, Ishibashi T, Takimoto H, Yamaguchi Y, Ohtaki H, Baba H. Intravenous immunoglobulin preparations attenuate lysolecithin-induced peripheral demyelination in mice and comprise anti-large myelin protein zero antibody. Proc Jpn Acad Ser B Phys Biol Sci. 2023;99(2):48-60. 2. Otani Y, Taguchi A, Hamada K, Hayashi Y, Yamaguchi Y, Baba H. Influence of novel readthrough agents on myelin protein zero translation in the peripheral nervous system. Neuropharmacology 211:109059. doi: 10.1016/j.neuropharm.2022.109059. Epub 2022 Apr 10. 3. Takanezawa Y, Tanabe S, Kato D, Ozeki R, Komoda M, Suzuki T, Baba H, Muramatsu R. Microglial ASD-related genes are involved in oligodendrocyte differentiation. Sci Rep. 11(1):17825. doi: 10.1038/s41598-021-97257-9. |
| 総説・解説 | 1. 2022 馬場広子 髄鞘研究への招待 YAKUGAKU ZASSHI 2022 年 142 巻 8 号 p. 837-853 2. 2022 Ishibashi T, Baba H. Paranodal Axoglial Junctions, an Essential Component in Axonal Homeostasis. Front Cell Dev Biol. 10:951809. doi: 10.3389/fcell.2022.951809. eCollection 2022. |
Profile
| Research Areas | Molecular Neurobiology |
|---|---|
| Research Introduction | Myelin is a multilamellar membrane structure that covers nerve fibers (axon) and facilitates rapid and efficient conduction of nerve impulses. Myelin is formed by two types of glial cells, oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS). Loss of myelin causes various demyelinating diseases in the CNS and/or PNS. Recent studies have revealed that myelin or myelin-forming cells interact with axons and regulate the nervous system far more actively than previously thought. My research interest is to understand the molecular mechanisms of myelin formation, function, and demyelination. |
| Books | Baba H and Ishibashi T. The role of sulfatides in axon-glia interaction. in Myelin Basic and Clinical Advances. edited by Sango K, Yamauchi J, Ogata T, Susuki K. Springer, 2020 |
| Papers | 1. 2023 Setoguchi Y, Hayashi A, Kawada A, Ibusuki A, Yanaoka D, Saito R, Ishibashi T, Takimoto H, Yamaguchi Y, Ohtaki H, Baba H. Intravenous immunoglobulin preparations attenuate lysolecithin-induced peripheral demyelination in mice and comprise anti-large myelin protein zero antibody. Proc Jpn Acad Ser B Phys Biol Sci. 2023;99(2):48-60. 2. 2022 Otani Y, Taguchi A, Hamada K, Hayashi Y, Yamaguchi Y, Baba H. Influence of novel readthrough agents on myelin protein zero translation in the peripheral nervous system. Neuropharmacology 211:109059. doi: 10.1016/j.neuropharm.2022.109059. Epub 2022 Apr 10. 3. 2021 Takanezawa Y, Tanabe S, Kato D, Ozeki R, Komoda M, Suzuki T, Baba H, Muramatsu R. Microglial ASD-related genes are involved in oligodendrocyte differentiation. Sci Rep. 11(1):17825. doi: 10.1038/s41598-021-97257-9. Otani Y, et al. Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice. Commun Biol. 13:121. doi: 10.1038/s42003-020-0854-z. (2020) Kunisawa K, et al. Dysregulation of schizophrenia-related aquaporin 3 through disruption of paranoid influences neuronal viability. J Neurochem. 147:395-408 (2018). Yamaguchi Y, Baba H. Phylogenetically conserved sequences around myelin P0 stop codon are essential for translational readthrough to produce L-MPZ. Neurochem Res. 43:227-237 (2018). Yamazaki R, et al. Unconventional myosin ID is involved in remyelination after cuprizone-induced demyelination. Neurochem Res. Oct 6. 43:195-204 (2018). Yamazaki R, et al. Expression of unconventional myosin VI in oligodendrocytes. Neurochem Res. Aug 21. doi:10.1007/s11064-017-2377-7 (2017). Yoshimura T, et al. GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system. Sci Rep. 7:42257 (2017). Yamazaki R, et al. Knockdown of Unconventional Myosin ID Expression Induced Morphological Change in Oligodendrocytes. ASN Neuro. 8(5). pii:1759091416669609 (2016). Kajigaya H, et al. Concentration of neddylation-related molecules in paranodal myelin of the peripheral nervous system. Proc Jpn Acad Ser B Phys Biol Sci. 92:56-68 (2016). Chiba T, et al. Microglial phospholipase D4 deficiency influences myelination during brain development. Proc Jpn Acad Ser B Phys Biol Sci. 92:237-254 (2016). |
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