医療技術学部 Department of Radiological Technology

診療放射線学科

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教員紹介

花村 健次写真

医療技術学部／診療放射線学科
Faculty of Medical Technology／Department of Radiological Technology

花村 健次
Kenji Hanamura
教授

プロフィール

担当科目生理学、人体の構造と機能Ⅰ・Ⅱ、臨床薬理学、感染症・免疫学、診療放射線学概論、総合演習Ⅰ
専門分野神経生物学、放射線生物学
キーワードシナプス、神経発達、放射線感受性
学位・称号／取得機関／取得年博士（理学）／大阪大学／2004
過去の経歴2002年 4月⁻ 岡崎国立共同研究機構基礎生物学研究所制御機構研究系行動制御研究部門 研究員（～2003.3）
2003年 4月- 群馬大学大学院医学系研究科高次細胞機能学講座 助手（～2008.3）
2008年 4月- 群馬大学大学院医学系研究科神経薬理学講座 助教（～2011.3）
2011年 4月- 米国ペンシルバニア大学医学部神経科学部門 研究員（～2011.8）
2011年 9月- 米国トーマスジェファーソン大学神経科学部門 研究員（～2015.3）
2015年 4月- 群馬大学大学院医学系研究科神経薬理学講座　助教（～2018.7）
2018年 8月- 群馬大学大学院医学系研究科神経薬理学講座　准教授（～2020.3）
2020年 4月- 群馬大学大学院医学系研究科薬理学講座　准教授（～2020.4）
2023年 5月- 新潟医療福祉大学医療技術学部診療放射線学科 教授（現在に至る）
2023年 5月- 群馬大学医学部医学科 非常勤講師（現在に至る）
2023年 5月- 群馬大学大学院医学系研究科 客員教授（現在に至る）
所属団体・学会等日本神経科学会、日本生理学会、日本神経化学会、北関東医学会、日本薬理学会、新潟医療福祉学会

業績等

研究領域神経化学・神経薬理学、機能生物化学関連、生理学、薬理学、神経科学、放射線生物学
研究紹介

脳腫瘍の放射線治療の際に、副作用として認知機能低下を引き起こす場合があります。一方で、三叉神経痛の治療の際にガンマナイフを用いた放射線治療を行う場合があります。私は、これまでに神経細胞の発達や機能などを制御するメカニズムを明らかにしてきており、神経細胞の放射線感受性、そして放射線障害を低減する方法についても解析しつつあります。神経細胞の放射線感受性のメカニズムを理解することは、放射線による認知機能低下を軽減し、三叉神経痛をはじめとする放射線治療の有効性を高めることにつながる可能性があります。

著書1. Yamamoto N, Takemoto M, Hattori Y, Hanamura K Development and Plasticity in Sensory Thalamus and Cortex 5. Molecular Basis for the Formation of Lamina-Specific Thalamocortical Projection Erzurumlu R, Guido W and Molnar Z Springer New York, NY 2006.10 79-91
2. 白尾智明、花村健次 オックスフォード・生理学 原書4版 Part Four 神経系と感覚 第10章：運動系の生理学 p.158-182 岡野栄之、鯉淵典之、植村慶一 丸善出版 2016.1.25 158-182
3. 花村健次, 白尾智明 iPS細胞の安全・高品質な作製技術 第3章 iPS細胞を用いた病態解明および医薬品評価技術の開発、第10節 ヒトiPS細胞由来神経細胞等を用いた医薬品の副作用予測 技術情報協会 2016.10 170-174
受賞歴1. 2009 第56回 北関東医学会総会優秀発表賞“樹状突起スパインの形態変化におけるドレブリンの役割” 竹田麗子, 山崎博幸, 花村健次, 白尾智明
2. 2010 第四回 乙卯研究所 研究助成 脳神経疾患 自己免疫疾患とレチノイド「成体脳における新生ニューロンの放射線感受性に対するレチノイドの影響」花村健次
3. 2010 第57回 北関東医学会総会優秀発表賞“樹状突起スパインにおけるドレブリンのアイソフォーム特異的な動態の制御機構” 鎌田洋輔, 花村健次, 山崎博幸, 白尾智明
4. 2019 Poster Award in the 11th Toyota Riken International Workshop, Actin Filament: beyond the atomic resolution structure. “An isoform-specific dynamics of F-actin-binding protein drebrin in dendritic spines of neurons” 　Kenji Hanamura
研究論文（英文）1. Yamamoto N, Matsuyama Y, Harada A, Inui K, Murakami F, Hanamura K Characterization of factors regulating lamina-specific growth of thalamocortical axons. J Neurobiol. 2000.1 42: 56-68.
2. Yamamoto N, Inui K, Matsuyama Y, Harada A, Hanamura K, Murakami F, Ruthazer ES, Rutishauser U, Seki T. Inhibitory mechanism by polysialic acid for lamina-specific branch formation of thalamocortical axons. J. Neurosci. 2000.12 20: 9145-9151.
3. Hanamura K, Harada A, Katoh-Semba R, Murakami F, Yamamoto N. BDNF and NT-3 promote thalamocortical axon growth with distinct substrate and temporal dependency Eur. J. Neurosci. 2004.3 19: 1485-1493.
4. Aoki C, Sekino Y, Hanamura K, Fujisawa S, Mahadomrongkul V, Ren Y and Shirao T. Drebrin A is a Postsynaptic Protein that Localizes in vivo to the Submembranous Surface of Dendritic Sites Forming Excitatory Synapses. J. Comp. Neurol. 2005.3 483: 383-402.
5. Sekino Y, Tanaka S, Hanamura K, Yamazaki H, Sasagawa Y, Xue Y, Hayashi K, Shirao T. Activation of N-methyl-D-aspartate receptor induces a shift of drebrin distribution: disappearance from dendritic spines and appearance in dendritic shafts. Mol. Cell. Neurosci. 2006.3 31: 493-504.
6. Song M, Kojima N, Hanamura K, Sekino Y, Inoue HK, Mikuni M, Shirao T. Expression of drebrin E in migrating neuroblasts in adult rat brain: coincidence between drebrin E disappearance from cell body and cessation of migration. Neurosci. 2008.3 152: 670-682.
7. Mizui T, Kojima N, Yamazaki H, Katayama M, Hanamura K, Shirao T. Drebrin E is involved in the regulation of axonal growth through actin-myosin interactions. J. Neurochem. 2009.4 109: 611-622.
8. Takahashi H, Yamazaki H, Hanamura K, Sekino Y, Shirao T. Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis. J. Cell Sci. 2009.4 122: 1211-1219.
9. Aoki C, Kojima N, Sabaliauskas N, Shah L, Ahmed TH, Oakford J, Ahmed T, Yamazaki H, Hanamura K, Shirao T. Drebrin A knockout eliminates the rapid form of homeostatic synaptic plasticity at excitatory synapses of intact adult cerebral cortex. J. Comp. Neurol. 2009.11 517:105-121.
10. Kojima N, Hanamura K, Yamazaki H, Ikeda T, Itohara S, Shirao T Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Neurosci. 2010.1 165: 138-150.
11. Hanamura K, Mizui T, Kakizaki T, Roppongi RT, Yamazaki H, Yanagawa Y, Shirao　T. Low Accumulation of Drebrin at Glutamatergic Postsynaptic Sites on GABAergic Neurons. Neurosci. 2010.9 169: 1489-1500.
12. Tanaka K, Sato K, Yoshida T, Fukuda T, Hanamura K, Kojima N, Shirao T, Yanagawa T, Watanabe H. Evidence for cell density affecting C2C12 myogenesis: possible regulation of myogenesis by cell-cell communication. Muscle Nerve. 2011.12 44: 968-977.
13. Roppongi RT, Kojima N, Hanamura K, Yamazaki H, Shirao T. Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT2A receptors. Neurosci. Lett. 2013.6 547: 76-81.
14. Shirai K, Mizui T, Suzuki Y, Okamoto M, Hanamura K, Yoshida Y, Hino M, Noda SE, Al-Jahdari WS, Chakravarti A, Shirao T, Nakano T. X Irradiation Changes Dendritic Spine Morphology and Density through Reduction of Cytoskeletal Proteins in Mature Neurons. Radiat. Res. 2013.10 179: 630-636
15. Yamazaki H, Kojima N, Kato K, Hirose E, Iwasaki T, Mizui T, Takahashi H, Hanamura K, Roppongi RT, Koibuchi N, Sekino Y, Mori N, Shirao T. Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines. J. Neurochem. 2014.2 128: 507-522.
16. Kojima N, Yasuda H, Hanamura K, Ishizuka Y, Sekino Y, Shirao T. Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice Neurosci. 2016.6 324: 218-226.
17. Hanamura K, Washburn HR, Sheffler-Collins SI, Xia NL, Henderson N, Tillu DV, Hassler S, Spellman DS, Zhang G, Neubert TA, Price TJ, Dalva MB. Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain. PLoS Biol. 2017.7 15: e2002457.
18. Miao S, Koganezawa N, Hanamura K, Puspitasari A, Shirao T. N-methyl-D-aspartate receptor mediates X-irradiation-induced drebrin decrease in hippocampus. Kitakanto Medical Journal. 2018.5 68: 111-115.
19. Hanamura K*, Kamata Y, Yamazaki H, Kojima N, Shirao T. Isoform-dependent Regulation of Drebrin Dynamics in Dendritic Spines. Neurosci. 2018.5 379: 67-76.
20. Mao YT, Zhu JX, Hanamura K, Iurilli G, Datta SR, Dalva MB. Filopodia conduct target selection in cortical neurons using differences in signal kinetics of a single kinase. Neuron 2018.5 98: 767-782.
21. Yasuda H, Kojima N, Hanamura K, Yamazaki H, Sakimura K, Shirao T. Drebrin isoforms critically regulate NMDAR- and mGluR-dependent LTD induction. Front. Cell. Neurosci. 2018.10 12: 330.
22. Mitsuoka T, Hanamura K, Koganezawa N, Kikura-Hanajiri R, Sekino Y, Shirao T. Assessment of NMDA receptor inhibition of phencyclidine analogues using a high-throughput drebrin immunocytochemical assay. J. Pharmacol. Toxicol. Methods. 2019.9 99: 106583.
23. Hanamura K, Koganezawa N, Kamiyama K, Tanaka N, Oka T, Yamamura M, Sekino Y, Shirao T. High-content imaging analysis for detecting the loss of drebrin clusters along dendrites in cultured hippocampal neurons. J. Pharmacol. Toxicol. Methods. 2019.9 99: 106607.
24. Dombroski TCD, Peixoto-Santos JE, Maciel K, Baqui MMA, Velasco TR, Sakamoto AC, Assirati JA, Carlotti CG, Machado HR, Sousa GK, Hanamura K, Leite JP, Costa da Costa J, Palmini AL, Paglioli E, Neder L, Spreafico R, Shirao T, Garbelli R, Martins AR. Drebrin expression patterns in patients with refractory temporal lobe epilepsy and hippocampal sclerosis. Epilepsia 2020.8 61: 1581-1594.
25. Yasuda H, Yamamoto H, Hanamura K, Mehruba M, Kawamata T, Morisaki H, Miyamoto M, Takada S, Shirao T, Ono Y, Mukai H. PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation. Commun. Biol. 2020.11 3: 710
26. Ariyani W, Miyazaki W, Amano I, Hanamura K, Shirao T, Koibuchi N. Soy Isoflavones Accelerate Glial Cell Migration via GPER-Mediated Signal Transduction Pathway. Front. Endocrinol. 2020.11 11: 554941.
27. Koganezawa N, Hanamura K, Schwark M, Krueger-Burg D, Kawabe H. Super-resolved 3D-STED microscopy identifies a layer-specific increase in excitatory synapses in the hippocampal CA1 region of Neuroligin-3 KO mice. Biochem Biophys Res Commun 2021.12 582: 144-149.
28. Puspitasari A, Squarcio F, Quartieri M, Totis C, Hitrec T, Takahashi A, Yoshida Y, Hanamura K, Yako T, Cerri M, Simoniello P, Durante M, Tinganelli W Synthetic torpor protects rats from exposure to accelerated heavy ions. Sci Rep 2022.9 12: 16405.
29. Xie MJ, Yagi H, Iguchi T, Yamazaki H, Hanamura K, Matsuzaki H, Shirao T, Sato M. Phldb2 is essential for regulating hippocampal dendritic spine morphology through　drebrin in an adult-type isoform-specific manner Neurosci Res 2022.12 185: 1-10.
30. Katsube S, Koganezawa N, Hanamura K, Cuthill KJ, Tarabykin V, Ambrozkiewicz MC, Kawabe H. The murine ortholog of Kaufman oculocerebrofacial syndrome gene Ube3b is crucial for the maintenance of the excitatory synapses in the young adult stage. Neurosci Lett 2023.2 797: 137059
31. Yamamura M, Hanamura K, Koganezawa N, Furubayashi S, Shirao T, Kawabe H. Impacts of methotrexate on survival, dendrite development, and synapse formation of cortical neurons. Genes Cells in press in press
総説・解説1. 2005 Yamamoto N, Hanamura K. Formation of the Thalamocortical Projection Regulated differentially by BDNF- and NT-3-Mediated Signaling. Rev. Neurosci. 2005.6 16: 223-231.
2. 2007 花村健次, 白尾智明 神経細胞樹状突起スパインのアクチン細胞骨格. 日本薬理学雑誌 2007.11 130巻 352-357.
3. 2016 小金澤紀子, 花村健次, 白尾智明 ヒトiPS細胞由来神経細胞を用いた医薬品評価系の現状について. 日本薬理学雑誌 2017.3 149巻, 1-6.
4. 2017 Shirao T, Hanamura K, Koganezawa N, Ishizuka Y, Yamazaki H, Sekino Y. The role of drebrin in neurons. J. Neurochem. 2017.6 141: 819-834.
5. 2017 Shirao T, Koganezawa N, Yamazaki H, Hanamura K, Imamura K. Localization of Drebrin: Light Microscopy Study. Adv. Exp. Med. Biol. 2017.9 1006: 105-118.
6. 2017 Hanamura K Drebrin in neuronal migration and axonal growth. Adv. Exp. Med. Biol. 2017.9 1006: 141-155.
7. 2017 Ishizuka Y, Hanamura K Drebrin in Alzheimer’s disease. Adv. Exp. Med. Biol. 2017.9 1006: 203-223.
8. 2017 Koganezawa N, Hanamura K, Sekino Y, Shirao T. The role of drebrin in dendritic spines. Mol. Cell. Neurosci. 2017.10 84: 85-92.
9. 2020 Puspitasari A, Cerri M, Takahashi A, Yoshida Y, Hanamura K, Tinganelli W. Hibernation as a Tool for Radiation-protection in Space Exploration. Life 2021.1 11: 54.
科学研究費1. 2004-2006年度 14,800千円 基盤研究（B） 神経回路形成時の軸索成長円錐におけるアクチン細胞骨格の役割
2. 2010年度 1,500千円 その他 放射線感受性による神経細胞分化の脳内マッピング
3. 2015-2016年度 2,990千円 その他 加齢脳特異的シナプス機能異常マウスにおける神経活動依存性NMDA受容体動態の解析
4. 2017-2019年度 17,810千円 特別推進研究 アクチン動態に基づく新たなシナプス可塑性モデル
5. 2020-2022年度（1年延長） 4,290千円 基盤研究（C） FN3を持つ神経発達障害関連分子の細胞外チロシンリン酸化とその役割の解析
学会等研究発表1. Hanamura K, Koganezawa N, Sekino Y and Shirao T High-content Imaging Analysis For Detecting The Status Of Synapses In Cultured Hippocampal Neurons. Society of Toxicology (SOT) 57th Annual Meeting 3/11/2018-3/15/2018
2. Kenji Hanamura, Yuko Sekino, Tomoaki Shirao High-content imaging analysis of the status of synapses using drebrin in cultured neurons. 18th World Congress of Basic and Clinical Pharmacology (WCP2018) 7/1/2018-7/6/2018
3. 花村健次, 小金澤紀子, 関野祐子, 白尾智 High-content imaging analysis of synaptic status in cultured neurons : evaluation of activity-dependent regulation of drebrin clusters along dendrites by NMDA receptors. 第41回日本神経科学大会 7/26/2018-7/29/2018
4. Kenji Hanamura, Shuchuan Miao, Natsume Tanaka, Noriko Koganezawa, Anggraeini Puspitasari, Hidetaka Ueno, Takaaki Suzuki, Tomoaki Shirao High-throughput imaging analysis for detecting the effects of irradiation on synaptic status. The 9th International Society of Radiation Neurobiology Conference (ISRN2019) 2/15/2019-2/16/2019
5. Kenji Hanamura, Toshinari Mitsuoka, Ruri Kikura-Hanajiri, Yuko Sekino, Tomoaki Shirao High-throughput imaging analysis using cultured neurons for detecting phencyclidine-like substances. The 9th Federation of the Asian and Oceanian Physiological Societies Congress 3/28/2019-3/31/2019
6. Kenji Hanamura Extracellular EphB tyrosine phosphorylation regulates EphB-NMDAR interaction and synaptic accumulation of NMDARs Development and Plasticity of the Brain 10/21/2022-10/23/2022
知的財産権1. シナプス成熟障害モデル動物 白尾智明, 児島伸彦, 山崎博幸, 関野祐子, 花村健次 2004年9月3日 特願2004-257060, 特開2006-67944
2. ドレブリンに特異的に結合するペプチド、及びそのペプチドを用いたドレブリンの検出方法 白尾智明, 山崎博幸, 花村健次, 村上明一, 塚原成俊 2018年5月8日 特願2019-185245
3. アルツハイマー病モデル非ヒト動物及びその製造方法 白尾智明, 関野祐子, 花村健次, 山崎博幸, 小金澤紀子 2019年10月8日 特願2019-18524
4. NMDA受容体阻害活性のハイスループット評価方法 白尾智明, 光岡俊成, 花村健次, 小金澤紀子, 関野祐子 2020年3月12日 特願2019-46531, PCT/JP2020/010909

Profile

Research AreasNeurobiology, Radiation biology
Papers1. 1999 Yamamoto N, Matsuyama Y, Harada A, Inui K, Murakami F, Hanamura K Characterization of factors regulating lamina-specific growth of thalamocortical axons. J Neurobiol. 2000.1 42: 56-68.
2. 2000 Yamamoto N, Inui K, Matsuyama Y, Harada A, Hanamura K, Murakami F, Ruthazer ES, Rutishauser U, Seki T. Inhibitory mechanism by polysialic acid for lamina-specific branch formation of thalamocortical axons. J. Neurosci. 2000.12 20: 9145-9151.
3. 2003 Hanamura K, Harada A, Katoh-Semba R, Murakami F, Yamamoto N. BDNF and NT-3 promote thalamocortical axon growth with distinct substrate and temporal dependency Eur. J. Neurosci. 2004.3 19: 1485-1493.
4. 2004 Aoki C, Sekino Y, Hanamura K, Fujisawa S, Mahadomrongkul V, Ren Y and Shirao T. Drebrin A is a Postsynaptic Protein that Localizes in vivo to the Submembranous Surface of Dendritic Sites Forming Excitatory Synapses. J. Comp. Neurol. 2005.3 483: 383-402.
5. 2005 Sekino Y, Tanaka S, Hanamura K, Yamazaki H, Sasagawa Y, Xue Y, Hayashi K, Shirao T. Activation of N-methyl-D-aspartate receptor induces a shift of drebrin distribution: disappearance from dendritic spines and appearance in dendritic shafts. Mol. Cell. Neurosci. 2006.3 31: 493-504.
6. 2007 Song M, Kojima N, Hanamura K, Sekino Y, Inoue HK, Mikuni M, Shirao T. Expression of drebrin E in migrating neuroblasts in adult rat brain: coincidence between drebrin E disappearance from cell body and cessation of migration. Neurosci. 2008.3 152: 670-682.
7. 2009 Mizui T, Kojima N, Yamazaki H, Katayama M, Hanamura K, Shirao T. Drebrin E is involved in the regulation of axonal growth through actin-myosin interactions. J. Neurochem. 2009.4 109: 611-622.
8. 2009 Takahashi H, Yamazaki H, Hanamura K, Sekino Y, Shirao T. Activity of the AMPA receptor regulates drebrin stabilization in dendritic spine morphogenesis. J. Cell Sci. 2009.4 122: 1211-1219.
9. 2009 Aoki C, Kojima N, Sabaliauskas N, Shah L, Ahmed TH, Oakford J, Ahmed T, Yamazaki H, Hanamura K, Shirao T. Drebrin A knockout eliminates the rapid form of homeostatic synaptic plasticity at excitatory synapses of intact adult cerebral cortex. J. Comp. Neurol. 2009.11 517:105-121.
10. 2009 Kojima N, Hanamura K, Yamazaki H, Ikeda T, Itohara S, Shirao T Genetic disruption of the alternative splicing of drebrin gene impairs context-dependent fear learning in adulthood. Neurosci. 2010.1 165: 138-150.
11. 2010 Hanamura K, Mizui T, Kakizaki T, Roppongi RT, Yamazaki H, Yanagawa Y, Shirao　T. Low Accumulation of Drebrin at Glutamatergic Postsynaptic Sites on GABAergic Neurons. Neurosci. 2010.9 169: 1489-1500.
12. 2011 Tanaka K, Sato K, Yoshida T, Fukuda T, Hanamura K, Kojima N, Shirao T, Yanagawa T, Watanabe H. Evidence for cell density affecting C2C12 myogenesis: possible regulation of myogenesis by cell-cell communication. Muscle Nerve. 2011.12 44: 968-977.
13. 2013 Roppongi RT, Kojima N, Hanamura K, Yamazaki H, Shirao T. Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT2A receptors. Neurosci. Lett. 2013.6 547: 76-81.
14. 2013 Shirai K, Mizui T, Suzuki Y, Okamoto M, Hanamura K, Yoshida Y, Hino M, Noda SE, Al-Jahdari WS, Chakravarti A, Shirao T, Nakano T. X Irradiation Changes Dendritic Spine Morphology and Density through Reduction of Cytoskeletal Proteins in Mature Neurons. Radiat. Res. 2013.10 179: 630-636
15. 2013 Yamazaki H, Kojima N, Kato K, Hirose E, Iwasaki T, Mizui T, Takahashi H, Hanamura K, Roppongi RT, Koibuchi N, Sekino Y, Mori N, Shirao T. Spikar, a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines. J. Neurochem. 2014.2 128: 507-522.
16. 2016 Kojima N, Yasuda H, Hanamura K, Ishizuka Y, Sekino Y, Shirao T. Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice Neurosci. 2016.6 324: 218-226.
17. 2017 Hanamura K, Washburn HR, Sheffler-Collins SI, Xia NL, Henderson N, Tillu DV, Hassler S, Spellman DS, Zhang G, Neubert TA, Price TJ, Dalva MB. Extracellular phosphorylation of a receptor tyrosine kinase controls synaptic localization of NMDA receptors and regulates pathological pain. PLoS Biol. 2017.7 15: e2002457.
18. 2018 Miao S, Koganezawa N, Hanamura K, Puspitasari A, Shirao T. N-methyl-D-aspartate receptor mediates X-irradiation-induced drebrin decrease in hippocampus. Kitakanto Medical Journal. 2018.5 68: 111-115.
19. 2018 Hanamura K*, Kamata Y, Yamazaki H, Kojima N, Shirao T. Isoform-dependent Regulation of Drebrin Dynamics in Dendritic Spines. Neurosci. 2018.5 379: 67-76.
20. 2018 Mao YT, Zhu JX, Hanamura K, Iurilli G, Datta SR, Dalva MB. Filopodia conduct target selection in cortical neurons using differences in signal kinetics of a single kinase. Neuron 2018.5 98: 767-782.
21. 2018 Yasuda H, Kojima N, Hanamura K, Yamazaki H, Sakimura K, Shirao T. Drebrin isoforms critically regulate NMDAR- and mGluR-dependent LTD induction. Front. Cell. Neurosci. 2018.10 12: 330.
22. 2019 Mitsuoka T, Hanamura K, Koganezawa N, Kikura-Hanajiri R, Sekino Y, Shirao T. Assessment of NMDA receptor inhibition of phencyclidine analogues using a high-throughput drebrin immunocytochemical assay. J. Pharmacol. Toxicol. Methods. 2019.9 99: 106583.
23. 2019 Hanamura K, Koganezawa N, Kamiyama K, Tanaka N, Oka T, Yamamura M, Sekino Y, Shirao T. High-content imaging analysis for detecting the loss of drebrin clusters along dendrites in cultured hippocampal neurons. J. Pharmacol. Toxicol. Methods. 2019.9 99: 106607.
24. 2020 Dombroski TCD, Peixoto-Santos JE, Maciel K, Baqui MMA, Velasco TR, Sakamoto AC, Assirati JA, Carlotti CG, Machado HR, Sousa GK, Hanamura K, Leite JP, Costa da Costa J, Palmini AL, Paglioli E, Neder L, Spreafico R, Shirao T, Garbelli R, Martins AR. Drebrin expression patterns in patients with refractory temporal lobe epilepsy and hippocampal sclerosis. Epilepsia 2020.8 61: 1581-1594.
25. 2020 Yasuda H, Yamamoto H, Hanamura K, Mehruba M, Kawamata T, Morisaki H, Miyamoto M, Takada S, Shirao T, Ono Y, Mukai H. PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation. Commun. Biol. 2020.11 3: 710
26. 2020 Ariyani W, Miyazaki W, Amano I, Hanamura K, Shirao T, Koibuchi N. Soy Isoflavones Accelerate Glial Cell Migration via GPER-Mediated Signal Transduction Pathway. Front. Endocrinol. 2020.11 11: 554941.
27. 2021 Koganezawa N, Hanamura K, Schwark M, Krueger-Burg D, Kawabe H. Super-resolved 3D-STED microscopy identifies a layer-specific increase in excitatory synapses in the hippocampal CA1 region of Neuroligin-3 KO mice. Biochem Biophys Res Commun 2021.12 582: 144-149.
28. 2022 Puspitasari A, Squarcio F, Quartieri M, Totis C, Hitrec T, Takahashi A, Yoshida Y, Hanamura K, Yako T, Cerri M, Simoniello P, Durante M, Tinganelli W Synthetic torpor protects rats from exposure to accelerated heavy ions. Sci Rep 2022.9 12: 16405.
29. 2022 Xie MJ, Yagi H, Iguchi T, Yamazaki H, Hanamura K, Matsuzaki H, Shirao T, Sato M. Phldb2 is essential for regulating hippocampal dendritic spine morphology through　drebrin in an adult-type isoform-specific manner Neurosci Res 2022.12 185: 1-10.
30. 2022 Katsube S, Koganezawa N, Hanamura K, Cuthill KJ, Tarabykin V, Ambrozkiewicz MC, Kawabe H. The murine ortholog of Kaufman oculocerebrofacial syndrome gene Ube3b is crucial for the maintenance of the excitatory synapses in the young adult stage. Neurosci Lett 2023.2 797: 137059
31. 2023 Yamamura M, Hanamura K, Koganezawa N, Furubayashi S, Shirao T, Kawabe H. Impacts of methotrexate on survival, dendrite development, and synapse formation of cortical neurons. Genes Cells in press in press
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