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教員紹介

大西 秀明写真

リハビリテーション学部／理学療法学科
Faculty of Rehabilitation／Department of Physical Therapy

大西 秀明
Hideaki Onishi
研究・産官学連携担当副学長／リハビリテーション学部長／教授

プロフィール

担当科目神経筋機能解析学、理学療法ゼミ、卒業研究
専門分野基礎理学療法学、神経科学
学位・称号／取得機関／取得年博士（障害科学）／東北大学／2000年
資格理学療法士、専門理学療法士（基礎）
最終出身校東北大学大学院　医学系研究科
過去の経歴新潟医療福祉大学設立準備室専門委員を経て現職
所属団体・学会等日本理学療法士協会、日本基礎理学療法学会（副理事長）、日本臨床神経生理学会（代議員）、日本生体磁気学会（評議員）、全国大学理学療法学教育学会（理事長）、日本リハビリテーション医学会、日本体力医学会、新潟医療福祉学会

業績等

研究領域運動と感覚（体性感覚）に関する神経生理学的研究
研究紹介人がスムーズな動作を遂行するために必要な大脳皮質活動について、神経生理学的手法を利用して研究しています。
例えば、簡単な運動を行った際の大脳皮質の活動や、触覚刺激などを与えられた際の大脳皮質の活動をミリ秒単位で詳細に解析し、大脳のどの部位がどのようなタイミングで活動しているのかを研究しています。また、様々な外的刺激（電気刺激や磁気刺激、触覚刺激など）を与えることにより、大脳皮質の興奮性を変調させ、運動制御や運動学習に応用するための研究をしています。
著書Onishi H,　「Somatosensory system」､Tobimatsu S and Kakigi R ed. 「Clinical Applications of Magnetoencephalography」､Springer､2016；大西秀明「随意運動・他動運動・体性感覚刺激と皮質活動」、鈴木俊明、大西秀明編集「リハビリテーション神経科学」、メジカルビュー、2019；大西秀明「感覚入力と脳の可塑性」､金子文成，斎藤秀之編集「感覚入力で挑む」､文光堂､2016；大西秀明「筋電図」､小柳麿毅，西村敦，山下脇子，大西秀明編「運動学テキスト」、金原出版、2015；大西秀明「脳の構造と機能」､市橋則明編集「運動療法学第2版」、文光堂､2013；大西秀明「論文投稿」「研究助成」､内山靖編集「理学療法研究法第3版」､医学書院､2013；大西秀明，久保雅義「運動機能解析テクニック」、細田多穂編集「理学療法ハンドブック第4版」､協同医書､2010；大西秀明「随意運動のメカニズム」、吉尾雅春編集「運動療法学総論第2版」、医学書院、2010；大西秀明「MEG」､大西秀明､森岡周編集 「脳科学と理学療法」、三輪書店、2008；大西秀明「筋電計」､黒川幸雄､大西秀明､他編集 「臨床動作分析マニュアル」、文光堂、2006；他
研究論文1. Miyaguchi S, Inukai Y, Mitsumoto S, Otsuru N, Onishi H.: Gamma-transcranial alternating current stimulation on the cerebellum and supplementary motor area improves bimanual motor skill. Behav Brain Res.2022, 16:113805. doi:10.1016/j.bbr.2022.113805
2. Nagasaka K, Otsuru N, Sato R, Watanabe H, Sakurai N, Ohno K, Kodama N, Onishi H.: Cortical signature related to psychometric properties of pain vigilance in healthy individuals: A voxel-based morphometric study. Neurosci Lett. 2022, 16: 772:136445. doi:10.1016/j.neulet.2022.136445
3. Ikarashi H, Otsuru N, Yokota H, Nagasaka K, Igarashi K, Miyaguchi S, Onishi H.: Influence of Catechol-O-Methyltransferase Gene Polymorphism on the Correlation between Alexithymia and Hypervigilance to Pain. Int J Environ Res Public Health. 2021. 16: 18(24):13265. doi:10.3390/ijerph182413265
4. Sakurai N, Ohno K, Kasai S, Nagasaka K, Onishi H, Kodama N.: Induction of Relaxation by Autonomous Sensory Meridian Response. Front Behav Neurosci. 2021, 30: 15:761621. doi:10.3389/fnbeh.2021.761621
5. Sasaki R, Miyaguchi S, Onishi H.: Effect of brain-derived neurotrophic factor gene polymorphisms on motor performance and motor learning: A systematic review and meta-analysis. Behav Brain Res. 2022, 26: 420:113712. doi:10.1016/j.bbr.2021.113712
6. Miyaguchi S, Inukai Y, Hashimoto I, Otsuru N, Onishi H.: Sleep affects the motor memory of basketball shooting skills in young amateurs. J Clin Neurosci. 2022, 96:187-193. doi:10.1016/j.jocn.2021.11.016
7. Kojima S, Miyaguchi S, Yokota H, Saito K, Inukai Y, Otsuru N, Onishi H.: The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability. Brain Sci. 2021, 12: 11(11):1494. doi:10.3390/brainsci11111494
8. Morishita S, Hirabayashi R, Tsubaki A, Aoki O, Fu JB, Onishi H, Tsuji T.: Relationship between balance function and QOL in cancer survivors and healthy subjects. Medicine (Baltimore)2021, 19: 100(46):e27822. doi:10.1097/MD.0000000000027822
9. Sakai S, Saito K, Kojima S, Otsuru N, Onishi H.: Grating orientation task trial numbers for short- and long-term tactile discrimination learning. J Clin Neurosci. 2021, 93:195-199. doi:10.1016/j.jocn.2021.08.026
10. Sasaki R, Kojima S, Onishi H.: Do Brain-Derived Neurotrophic Factor Genetic Polymorphisms Modulate the Efficacy of Motor Cortex Plasticity Induced by Non-invasive Brain Stimulation? A Systematic Review. Front Hum Neurosci. 2021, 28: 15:742373. doi:10.3389/fnhum.2021.742373
11. Watanabe H, Kojima S, Nagasaka K, Ohno K, Sakurai N, Kodama N, Otsuru N, Onishi H.: Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype. Cereb Cortex. 2021, 11:bhab370. doi:10.1093/cercor/bhab370
12. Otsuru N, Ogawa M, Yokota H, Miyaguchi S, Kojima S, Saito K, Inukai Y, Onishi H.: Auditory change-related cortical response is associated with hypervigilance to pain in healthy volunteers. Eur J Pain. 2022, 26(2):349-355. doi:10.1002/ejp.1863
13. Hoshi H, Kojima S, Otsuru N, Onishi H.: Effects of transcranial random noise stimulation timing on corticospinal excitability and motor function. Behav Brain Res. 2021, 24: 414:113479. doi:10.1016/j.bbr.2021.113479
14. Sasaki R, Watanabe H, Miyaguchi S, Otsuru N, Ohno K, Sakurai N, Kodama N, Onishi H.: Contribution of the brain-derived neurotrophic factor and neurometabolites to the motor performance. Behav Brain Res. 2021, 27: 412:113433. doi:10.1016/j.bbr.2021.113433
15. Oyanagi K, Kitai T, Yoshimura Y, Yokoi Y, Ohara N, Kohara N, Sakai N, Honda A, Onishi H, Iwata K.: Effect of early intensive rehabilitation on the clinical outcomes of patients with acute stroke. Geriatr Gerontol Int. 2021, 21(8):623-628. doi:10.1111/ggi.14202
16. Hirabayashi R, Edama M, Saito A, Yamada Y, Nawa R, Onishi H.: Effects of Clenching Strength on Exercise Performance: Verification Using Spinal Function Assessments. Sports Health. 2021, 29:19417381211014836. doi:10.1177/19417381211014836
17. Tsubaki A, Morishita S, Hotta K, Tokunaga Y, Qin W, Kojima S, Onishi H.: Changes in the Laterality of Oxygenation in the Prefrontal Cortex and Premotor Area During a 20-Min Moderate-Intensity Cycling Exercise. Adv Exp Med Biol. 20211, 269:113-117. doi:10.1007/978-3-030-48238-1_18
18. Morishita S, Tsubaki A, Hotta K, Kojima S, Sato D, Shirayama A, Ito Y, Onishi H.: Relationship Between the Borg Scale Rating of Perceived Exertion and Leg-Muscle Deoxygenation During Incremental Exercise in Healthy Adults. Adv Exp Med Biol. 2021, 1269:95-99. doi:10.1007/978-3-030-48238-1_15
19. Sasaki R, Otsuru N, Miyaguchi S, Kojima S, Watanabe H, Ohno K, Sakurai N, Kodama N, Sato D, Onishi H.: Influence of Brain-Derived Neurotrophic Factor Genotype on Short-Latency Afferent Inhibition and Motor Cortex Metabolites. Brain Sci. 2021, 20: 11(3):395. doi:10.3390/brainsci11030395
20. Kojima S, Otsuru N, Miyaguchi S, Yokota H, Nagasaka K, Saito K, Inukai Y, Shirozu H, Onishi H.: The intervention of mechanical tactile stimulation modulates somatosensory evoked magnetic fields and cortical oscillations. Eur J Neurosci. 2021, 53(10):3433-3446. doi:10.1111/ejn.15209
21. Yokota H, Otsuru N, Saito K, Kojima S, Miyaguchi S, Inukai Y, Nagasaka K, Onishi H.: Region-Specific Effects of 10-Hz Transcranial Alternate Current Stimulation Over the Left Posterior Parietal Cortex and Primary Somatosensory Area on Tactile Two-Point Discrimination Threshold. Front Neurosci. 2021, 18: 15:576526. doi:10.3389/fnins.2021.576526
22. Pham MV, Miyaguchi S, Watanabe H, Saito K, Otsuru N, Onishi H.: Effect of Repetitive Passive Movement Before Motor Skill Training on Corticospinal Excitability and Motor Learning Depend on BDNF Polymorphisms. Front Hum Neurosci. 2021, 5: 15:621358. doi:10.3389/fnhum.2021.621358
23. Hoshi H, Kojima S, Otsuru N, Onishi H.: Corticospinal excitability of untrained side depends on the type of motor task and degree of improvement in motor function. Brain Cogn. 2021, 148:105691. doi:10.1016/j.bandc.2021.105691
24. Yamashiro K, Yamazaki Y, Siiya K, Ikarashi K, Baba Y, Otsuru N, Onishi H, Sato D.: Modality-specific improvements in sensory processing among baseball players. Sci Rep. 2021, 26: 11(1):2248. doi:10.1038/s41598-021-81852-x
25. Saito K, Otsuru N, Yokota H, Inukai Y, Miyaguchi S, Kojima S, Onishi H.: α-tACS over the somatosensory cortex enhances tactile spatial discrimination in healthy subjects with low alpha activity. Brain Behav. 2021,11(3):e02019. doi:10.1002/brb3.2019
26. Inukai Y, Miyaguchi S, Kobayashi N, Otsuru N, Onishi H.: Noisy galvanic vestibular stimulation effect on center of pressure sway during one-legged standing. J Clin Neurosci. 2020, 82(Pt: A):173-178. doi:10.1016/j.jocn.2020.10.050
27. Morishita S, Tsubaki A, Hotta K, Inoue T, Qin W, Kojima S, Fu JB, Onishi H.: Face Pain Scale and Borg Scale compared to physiological parameters during cardiopulmonary exercise testing. J Sports Med Phys Fitness. 2021, 61(11):1464-1468. doi:10.23736/S0022-4707.20.11815-2
他, 110偏
研究業績1) 2020年度～：小脳の構造・機能・ネットワーク解析による「研ぎ澄まされた感覚」の可視化 （文部科学省・挑戦的研究（開拓），代表）
2) 2019年度～：知覚学習イノベーション－次世代感覚運動学習法の創出を目指してー（文部科学省・基盤研究（A），代表）
3) 2016-2018年度：運動学習および感覚学習過程における皮質内抑制回路の役割（文部科学省・基盤研究（B），代表）
4) 2013-2015年度：運動遂行に伴う感覚情報処理に関する神経基盤の解明－MEGとTMSを併用した研究－･（文部科学省・基盤研究（B），代表）
5) 2010-2012年度：運動遂行に伴う感覚情報処理機構の解明－脳磁図を用いた研究－（文部科学省・基盤（B），代表）
6) 2009-2011年度：運動遂行時における脳血液量と体循環との関係（文部科学省・挑戦的萌芽研究，代表）
7) 2007-2009年度：運動遂行時における一次感覚野および運動前野の役割について（文部科学省・基盤（B），代表）
8) 2005・2006年度：ヒト随意運動時における筋出力および関節角度変化が運動関連脳磁場に与える影響（文部科学省・若手（B），代表）
9) 2003・2004年度：膝関節6自由度運動解析と臨床応用（文部科学省・若手（B），代表）
教育に関する活動全国大学理学療法学教育学会（理事長）
社会的活動日本基礎理学療法学会（副理事長），日本生体磁気学会（評議員），日本臨床神経生理学会（代議員），全国大学理学療法学教育学会（理事長）

Profile

Research AreasNeuroscience
Research Introductionsensorimotor integration / motor and perceptual learning
BooksOnishi H: Somatosensory system. Tobimatsu S and Kakigi R ed. Clinical Applications of Magnetoencephalography. Springer. 2016
PapersResearchmap: https://researchmap.jp/read0191448

(Recent Articles)
1. Miyaguchi S, Inukai Y, Mitsumoto S, Otsuru N, Onishi H.: Gamma-transcranial alternating current stimulation on the cerebellum and supplementary motor area improves bimanual motor skill. Behav Brain Res.2022, 16:113805. doi:10.1016/j.bbr.2022.113805
2. Nagasaka K, Otsuru N, Sato R, Watanabe H, Sakurai N, Ohno K, Kodama N, Onishi H.: Cortical signature related to psychometric properties of pain vigilance in healthy individuals: A voxel-based morphometric study. Neurosci Lett. 2022, 16: 772:136445. doi:10.1016/j.neulet.2022.136445
3. Ikarashi H, Otsuru N, Yokota H, Nagasaka K, Igarashi K, Miyaguchi S, Onishi H.: Influence of Catechol-O-Methyltransferase Gene Polymorphism on the Correlation between Alexithymia and Hypervigilance to Pain. Int J Environ Res Public Health. 2021. 16: 18(24):13265. doi:10.3390/ijerph182413265
4. Sakurai N, Ohno K, Kasai S, Nagasaka K, Onishi H, Kodama N.: Induction of Relaxation by Autonomous Sensory Meridian Response. Front Behav Neurosci. 2021, 30: 15:761621. doi:10.3389/fnbeh.2021.761621
5. Sasaki R, Miyaguchi S, Onishi H.: Effect of brain-derived neurotrophic factor gene polymorphisms on motor performance and motor learning: A systematic review and meta-analysis. Behav Brain Res. 2022, 26: 420:113712. doi:10.1016/j.bbr.2021.113712
6. Miyaguchi S, Inukai Y, Hashimoto I, Otsuru N, Onishi H.: Sleep affects the motor memory of basketball shooting skills in young amateurs. J Clin Neurosci. 2022, 96:187-193. doi:10.1016/j.jocn.2021.11.016
7. Kojima S, Miyaguchi S, Yokota H, Saito K, Inukai Y, Otsuru N, Onishi H.: The Number or Type of Stimuli Used for Somatosensory Stimulation Affected the Modulation of Corticospinal Excitability. Brain Sci. 2021, 12: 11(11):1494. doi:10.3390/brainsci11111494
8. Morishita S, Hirabayashi R, Tsubaki A, Aoki O, Fu JB, Onishi H, Tsuji T.: Relationship between balance function and QOL in cancer survivors and healthy subjects. Medicine (Baltimore)2021, 19: 100(46):e27822. doi:10.1097/MD.0000000000027822
9. Sakai S, Saito K, Kojima S, Otsuru N, Onishi H.: Grating orientation task trial numbers for short- and long-term tactile discrimination learning. J Clin Neurosci. 2021, 93:195-199. doi:10.1016/j.jocn.2021.08.026
10. Sasaki R, Kojima S, Onishi H.: Do Brain-Derived Neurotrophic Factor Genetic Polymorphisms Modulate the Efficacy of Motor Cortex Plasticity Induced by Non-invasive Brain Stimulation? A Systematic Review. Front Hum Neurosci. 2021, 28: 15:742373. doi:10.3389/fnhum.2021.742373
11. Watanabe H, Kojima S, Nagasaka K, Ohno K, Sakurai N, Kodama N, Otsuru N, Onishi H.: Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype. Cereb Cortex. 2021, 11:bhab370. doi:10.1093/cercor/bhab370
12. Otsuru N, Ogawa M, Yokota H, Miyaguchi S, Kojima S, Saito K, Inukai Y, Onishi H.: Auditory change-related cortical response is associated with hypervigilance to pain in healthy volunteers. Eur J Pain. 2022, 26(2):349-355. doi:10.1002/ejp.1863
13. Hoshi H, Kojima S, Otsuru N, Onishi H.: Effects of transcranial random noise stimulation timing on corticospinal excitability and motor function. Behav Brain Res. 2021, 24: 414:113479. doi:10.1016/j.bbr.2021.113479
14. Sasaki R, Watanabe H, Miyaguchi S, Otsuru N, Ohno K, Sakurai N, Kodama N, Onishi H.: Contribution of the brain-derived neurotrophic factor and neurometabolites to the motor performance. Behav Brain Res. 2021, 27: 412:113433. doi:10.1016/j.bbr.2021.113433
15. Oyanagi K, Kitai T, Yoshimura Y, Yokoi Y, Ohara N, Kohara N, Sakai N, Honda A, Onishi H, Iwata K.: Effect of early intensive rehabilitation on the clinical outcomes of patients with acute stroke. Geriatr Gerontol Int. 2021, 21(8):623-628. doi:10.1111/ggi.14202
16. Hirabayashi R, Edama M, Saito A, Yamada Y, Nawa R, Onishi H.: Effects of Clenching Strength on Exercise Performance: Verification Using Spinal Function Assessments. Sports Health. 2021, 29:19417381211014836. doi:10.1177/19417381211014836
17. Tsubaki A, Morishita S, Hotta K, Tokunaga Y, Qin W, Kojima S, Onishi H.: Changes in the Laterality of Oxygenation in the Prefrontal Cortex and Premotor Area During a 20-Min Moderate-Intensity Cycling Exercise. Adv Exp Med Biol. 2021, 269:113-117. doi:10.1007/978-3-030-48238-1_18
18. Morishita S, Tsubaki A, Hotta K, Kojima S, Sato D, Shirayama A, Ito Y, Onishi H.: Relationship Between the Borg Scale Rating of Perceived Exertion and Leg-Muscle Deoxygenation During Incremental Exercise in Healthy Adults. Adv Exp Med Biol. 2021, 1269:95-99. doi:10.1007/978-3-030-48238-1_15
19. Sasaki R, Otsuru N, Miyaguchi S, Kojima S, Watanabe H, Ohno K, Sakurai N, Kodama N, Sato D, Onishi H.: Influence of Brain-Derived Neurotrophic Factor Genotype on Short-Latency Afferent Inhibition and Motor Cortex Metabolites. Brain Sci. 2021, 20: 11(3):395. doi:10.3390/brainsci11030395
20. Kojima S, Otsuru N, Miyaguchi S, Yokota H, Nagasaka K, Saito K, Inukai Y, Shirozu H, Onishi H.: The intervention of mechanical tactile stimulation modulates somatosensory evoked magnetic fields and cortical oscillations. Eur J Neurosci. 2021, 53(10):3433-3446. doi:10.1111/ejn.15209
21. Yokota H, Otsuru N, Saito K, Kojima S, Miyaguchi S, Inukai Y, Nagasaka K, Onishi H.: Region-Specific Effects of 10-Hz Transcranial Alternate Current Stimulation Over the Left Posterior Parietal Cortex and Primary Somatosensory Area on Tactile Two-Point Discrimination Threshold. Front Neurosci. 2021, 18: 15:576526. doi:10.3389/fnins.2021.576526
22. Pham MV, Miyaguchi S, Watanabe H, Saito K, Otsuru N, Onishi H.: Effect of Repetitive Passive Movement Before Motor Skill Training on Corticospinal Excitability and Motor Learning Depend on BDNF Polymorphisms. Front Hum Neurosci. 2021, 5: 15:621358. doi:10.3389/fnhum.2021.621358
23. Hoshi H, Kojima S, Otsuru N, Onishi H.: Corticospinal excitability of untrained side depends on the type of motor task and degree of improvement in motor function. Brain Cogn. 2021, 148:105691. doi:10.1016/j.bandc.2021.105691
24. Yamashiro K, Yamazaki Y, Siiya K, Ikarashi K, Baba Y, Otsuru N, Onishi H, Sato D.: Modality-specific improvements in sensory processing among baseball players. Sci Rep. 2021, 26: 11(1):2248. doi:10.1038/s41598-021-81852-x
25. Saito K, Otsuru N, Yokota H, Inukai Y, Miyaguchi S, Kojima S, Onishi H.: α-tACS over the somatosensory cortex enhances tactile spatial discrimination in healthy subjects with low alpha activity. Brain Behav. 2021,11(3):e02019. doi:10.1002/brb3.2019
26. Inukai Y, Miyaguchi S, Kobayashi N, Otsuru N, Onishi H.: Noisy galvanic vestibular stimulation effect on center of pressure sway during one-legged standing. J Clin Neurosci. 2020, 82(Pt: A):173-178. doi:10.1016/j.jocn.2020.10.050
27. Morishita S, Tsubaki A, Hotta K, Inoue T, Qin W, Kojima S, Fu JB, Onishi H.: Face Pain Scale and Borg Scale compared to physiological parameters during cardiopulmonary exercise testing. J Sports Med Phys Fitness. 2021, 61(11):1464-1468. doi:10.23736/S0022-4707.20.11815-2

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